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Scientific article
English

Temporal association as a prerequisite factor of valsartan-induced lithium toxicity

Contributors

Lazarczyk, Maciej Jakub; Giannakopoulos, Panteleimon

Published in

Bipolar disorders, vol. 16, no. 6, p. 662-666

Publication date

2014

Abstract

Lithium is often the mood stabilizer of choice for the treatment of type I bipolar disorder. However, side effects as well as the narrow therapeutic dosing range often complicate its use. Lithium toxicity can be fatal and its serum level needs to be closely monitored, especially at the time of introduction and titration, or whenever combined with potentially interacting drugs, such as inhibitors of angiotensin-converting enzyme (ACE-I) or angiotensin receptor 1 (AT1 ) blockers. ACE-I and AT1 blockers can increase serum lithium levels, leading to acute lithium toxicity upon their introduction or titration.

Keywords

  • Aged
  • Angiotensin II Type 1 Receptor Blockers/adverse effects
  • Antimanic Agents/adverse effects/blood/urine
  • Bipolar Disorder/blood/drug therapy
  • Creatinine/blood/urine
  • Drug Synergism
  • Female
  • Humans
  • Lithium Chloride/adverse effects/blood/urine
  • Tetrazoles/adverse effects
  • Valine/adverse effects/analogs & derivatives

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

LAZARCZYK, Maciej Jakub, GIANNAKOPOULOS, Panteleimon. Temporal association as a prerequisite factor of valsartan-induced lithium toxicity. In: Bipolar disorders, 2014, vol. 16, n° 6, p. 662–666. doi: 10.1111/bdi.12174

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1398-5647
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Technical informations

Creation

27/09/2015 10:12:00

First validation

27/09/2015 10:12:00

Update

14/03/2023 23:48:51

Status update

14/03/2023 23:48:51

Last indexation

31/10/2024 01:52:04
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