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Temporal association as a prerequisite factor of valsartan-induced lithium toxicity

Lazarczyk, Maciej Jakub
Published in Bipolar disorders. 2014, vol. 16, no. 6, p. 662-666
Abstract Lithium is often the mood stabilizer of choice for the treatment of type I bipolar disorder. However, side effects as well as the narrow therapeutic dosing range often complicate its use. Lithium toxicity can be fatal and its serum level needs to be closely monitored, especially at the time of introduction and titration, or whenever combined with potentially interacting drugs, such as inhibitors of angiotensin-converting enzyme (ACE-I) or angiotensin receptor 1 (AT1 ) blockers. ACE-I and AT1 blockers can increase serum lithium levels, leading to acute lithium toxicity upon their introduction or titration.
Keywords AgedAngiotensin II Type 1 Receptor Blockers/adverse effectsAntimanic Agents/adverse effects/blood/urineBipolar Disorder/blood/drug therapyCreatinine/blood/urineDrug SynergismFemaleHumansLithium Chloride/adverse effects/blood/urineTetrazoles/adverse effectsValine/adverse effects/analogs & derivatives
PMID: 24372930
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Research group Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
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LAZARCZYK, Maciej Jakub, GIANNAKOPOULOS, Panteleimon. Temporal association as a prerequisite factor of valsartan-induced lithium toxicity. In: Bipolar disorders, 2014, vol. 16, n° 6, p. 662-666. doi: 10.1111/bdi.12174 https://archive-ouverte.unige.ch/unige:77121

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Deposited on : 2015-11-11

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