"Current state and prospects in managing liver transplanted children"

Pfister, E D; Mclin, Valérie Anne; Hierro, L; Tizzard, S A; Baumann, U

doi:10.1016/j.clinre.2014.08.005

Scientific article

English

"Current state and prospects in managing liver transplanted children"

Contributors

Pfister, E D; Mclin, Valérie Anne; Hierro, L; Tizzard, S A; Baumann, U

Published in

Clinics and research in hepatology and gastroenterology, vol. 39, no. 3, p. 292-295

Publication date

2015

Abstract

Pediatric liver transplantation (LTx) has revolutionized life chances and perspectives of children with liver disease. Following rapid establishment of the therapeutic concept in the early years of pediatric transplant medicine, more aspects beyond plain survival become increasingly important. In addition to improving the short to medium-term survival rates, researchers are focusing on themes such as rehabilitation, adherence and quality of life, long-term graft fibrosis and dysfunction, as well as the consequences of long-term immunosuppression. Also, more protocol biopsy data are available to evaluate increasing graft fibrosis. To manage their conditions, patients will need access to highly experienced pediatric liver transplant centers where clinical research will examine modulators of renal disease, endocrine and cardiovascular comorbidity and the development of graft fibrosis and malignancies. Assessment and evaluation of health-related quality of life and factors which influence clinical tolerance, adherence and transition from child to adult care will also be investigated. The analysis of multi-national registry data and more than 40years of experience with large patient cohorts will provide important clues to treatment and will thus get increasing attention. In the future, longitudinal assessment of the outcome for pediatric LTx patients should include more functional aspects than plain survival rates or laboratory parameters.

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

UNIGE research groups

Pathologies hépatiques congénitales et acquises de l'enfant (900)

Citation (ISO format)

PFISTER, E D et al. ‘Current state and prospects in managing liver transplanted children’. In: Clinics and research in hepatology and gastroenterology, 2015, vol. 39, n° 3, p. 292–295. doi: 10.1016/j.clinre.2014.08.005

Article (Published version)

Identifiers

PID : unige:76374
DOI : 10.1016/j.clinre.2014.08.005
PMID : 25241997

Journal ISSN

2210-7401

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Creation

17/09/2015 12:06:00

First validation

17/09/2015 12:06:00

Update

19/09/2025 10:14:23

Status update

19/09/2025 10:14:23

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19/09/2025 10:18:26

"Current state and prospects in managing liver transplanted children"

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation