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Activity-Dependent control over neocortical neuron differentiation and identity

Defense Thèse de doctorat : Univ. Genève et Lausanne, 2015 - Neur. 130 - 2015/09/17
Abstract During neocortical development, distinct yet related subtypes of neurons assemble through intracortical connections to form the circuits controlling mammalian high-skilled behaviors. These intracortical projections arise from two subtypes of excitatory neurons: layer (L) 4 neurons, which receive thalamocortical (TC) input and project locally within a cortical area, and L2/3 neurons, which receive L4 input and have long-range connections to other cortical areas. While the developmental mechanisms distinguishing intracortically-projecting from subcortically-projecting neurons are increasingly understood, how distinct subtypes of intracortically-projecting neurons emerge is unknown. Given the exquisite sensitivity of L4 neurons to TC synaptic activity during postnatal development, one possibility is that activity-dependent processes also act earlier during corticogenesis to delineate the identity of L4 neurons from that of next-born L2/3 neurons. To test this hypothesis, we selectively manipulated the excitability of L4 neurons during embryonic development. For this ...
Keywords Neocortical developmental, activity-dependent mechanisms, neuronal identity
URN: urn:nbn:ch:unige-757537
Note Thèse en Neurosciences des universités de Genève et de Lausanne
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Research group Neurobiologie développementale et plasticité (880)
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VITALI, Ilaria. Activity-Dependent control over neocortical neuron differentiation and identity. Université de Genève. Thèse, 2015. https://archive-ouverte.unige.ch/unige:75753

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Deposited on : 2015-10-05

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