Human rhinoviruses (HRV) are the most common respiratory viruses identified in humans with respiratory infections. HRV-induced wheezing during early life is strongly associated with the later development of asthma. However, detailed information is lacking on prevalence of HRV types and their association with respiratory symptoms. We therefore investigated the prevalence of HRV types in nasal swabs of 20 unselected healthy infants and its association with respiratory symptoms on a weekly basis during the first year of life. HRV was detected in 261 out of 825 of all nasal swabs (32%). HRV species A (HRV-A) and -C were equally frequent (39%), followed by HRV-B (12%). 76 different HRV types were detected with A78, A16 and B6 being the most frequent ones. HRV species A and C tended to induce more respiratory symptoms than HRV-B. The presence of different HRV species and types in the airways and the association between HRV types and respiratory symptoms during infancy is highly heterogeneous and dynamic without any immediately recognizable pattern.