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Vitamin D supplementation during infancy is associated with higher bone mineral mass in prepubertal girls

Published in The Journal of clinical endocrinology and metabolism. 1999, vol. 84, no. 12, p. 4541-4
Abstract The objective of this study was to determine whether vitamin D supplementation of breast-fed infants during the first year of life is associated with greater bone mineral content and/or areal bone mineral density (aBMD) in later childhood. The design was a retrospective cohort study. One hundred and six healthy prepubertal Caucasian girls (median age, 8 yr; range, 7-9 yr) were classified as vitamin D supplemented or unsupplemented during the first year of life on the basis of a questionnaire sent to participating families and their pediatricians. Bone area (square centimeters) and bone mineral content (grams) were determined by dual energy x-ray absorptiometry at six skeletal sites. Vitamin D receptor (VDR) 3'-gene polymorphisms (BsmI) were also determined. The supplemented (n = 91) and unsupplemented (n = 15) groups were similar in terms of season of birth, growth in the first year of life, age, anthropometric parameters, and calcium intake at time of dual energy x-ray absorptiometry. The supplemented group had higher aBMD at the level of radial metaphysis (mean +/- SEM, 0.301+/-0.003 vs. 0.283+/-0.008; P = 0.03), femoral neck (0.638+/-0.007 vs. 0.584+/-0.021; P = 0.01), and femoral trochanter (0.508+/-0.006 vs. 0.474+/-0.016; P = 0.04). At the lumbar spine level aBMD values were similar (0.626+/-0.006 vs. 0.598+/-0.019; P = 0.1). In a multiple regression model taking into account the effects of vitamin D supplementation, height, and VDR genotype on aBMD (dependent variable), femoral neck aBMD remained higher by 0.045 g/cm2 in the supplemented group (P = 0.02). Vitamin D supplementation in infancy was found to be associated with increased aBMD at specific skeletal sites later in childhood in prepubertal Caucasian girls.
Keywords Absorptiometry, PhotonBone DensityBreast FeedingChildCohort StudiesDietary SupplementsFemaleHumansInfantPolymorphism, GeneticReceptors, Calcitriol/geneticsRetrospective StudiesVitamin D/administration & dosage
PMID: 10599715
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Research group Gastroentérologie et transplantation (pédiatrie) (181)
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ZAMORA, Samuel Antonio et al. Vitamin D supplementation during infancy is associated with higher bone mineral mass in prepubertal girls. In: The Journal of clinical endocrinology and metabolism, 1999, vol. 84, n° 12, p. 4541-4. doi: 10.1210/jcem.84.12.6183 https://archive-ouverte.unige.ch/unige:73859

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Deposited on : 2015-07-02

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