Antiretroviral treatment and osteonecrosis in patients of the Swiss HIV Cohort Study: a nested case-control study

Hasse, Barbara; Ledergerber, Bruno; Egger, Mathias; Egger, Martin; Flepp, Markus; Bachmann, Stefano; Bernasconi, Enos; Guyot, Sophie; Hirschel, Bernard; Weber, Rainer; Gunthard, Huldrych

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Title		Antiretroviral treatment and osteonecrosis in patients of the Swiss HIV Cohort Study: a nested case-control study
Authors		Hasse, Barbara Ledergerber, Bruno Egger, Mathias Egger, Martin Flepp, Markus Bachmann, Stefano Bernasconi, Enos Guyot, Sophie Hirschel, Bernard Weber, Rainer Gunthard, Huldrych show all authors [1 - 11]
Published in		AIDS Research and Human Retroviruses. 2004, vol. 20, no. 9, p. 909-915
Abstract		We examined risk factors for avascular bone necrosis (AVN) particularly focusing o the question of whether antiretroviral treatment (ART) is associated with the emergence of osteonecrosis. After 11 years of following the entire cohort, 26 patients were found to have AVN. Compared to 260 concurrent HIV-infected controls, at risk when cases were diagnosed, patients with AVN had lower CD4 cell count nadirs (median 86.5 versus 137.5 cells/microl, p = 0.010) and suffered significantly more often from Pneumocystis pneumonia, cerebral toxoplasmosis, CMV retinitis, and atypical mycobacteriosis and had a significantly higher body mass index than controls. Duration of ART before AVN was not significantly different between cases and controls (2.92 versus 2.17 years, p = 0.30). In conclusion, AVN could not be attributed to time on antiretroviral treatment, but patients with AVN had histories of more severe immunosuppression and a higher body mass index than controls.
Keywords		Adult — Anti-HIV Agents/ adverse effects — Antiretroviral Therapy, Highly Active/ adverse effects — Case-Control Studies — Cohort Studies — Female — HIV Infections/ drug therapy/virology — Hiv-1 — Humans — Incidence — Male — Osteonecrosis/ chemically induced/epidemiology — Risk Factors
Identifiers		PMID: 15597520
Full text		Article - Limited access to UNIGE Other version: http://www.liebertonline.com/doi/abs/10.1089/aid.2004.20.909
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		HASSE, Barbara et al. Antiretroviral treatment and osteonecrosis in patients of the Swiss HIV Cohort Study: a nested case-control study. In: AIDS Research and Human Retroviruses, 2004, vol. 20, n° 9, p. 909-915. https://archive-ouverte.unige.ch/unige:7311