During the last decade, in-line skating has become an increasingly popular activity. Along with the number of reports, highlighting the number of injuries and their degree of severity, in-line skating injuries have to be considered a growing public health issue. The objective of this work is to report epidemiological knowledge about in-line skate injuries and ways of prevention. A thorough search of all reports and publications on the subject was performed through the Medline database and in references of selected publications. There are numerous case series studies and several observational ones, most of them undertaken in North America. In-line skates are used for recreation, sports, and transportation, in a variety of settings (parks, streets, bike path, etc.) and by most of age groups (5 to 71 years, median generally about 15). The most common site of injury is the wrist and forearm, although other parts of the body can be severely injured. Age, sex, physical training level, formal instruction level, lack of wearing of protective gear, skating location, may be risk factors for injury. Some preventive measures were proposed by a number of research workers (information campaigns, wearing of protective gear, instruction, laws, etc.). Several preventive attempts were undertaken but no one was appraised. In-line skates are used by all age groups and for a variety of activities. In-line skating is related to a great number of factors, such as cultural, social, geographic, urban and behavioural factors. Therefore, groups at risk for injury are very different. Emergence of an important type of injury should lead to the development of analytic epidemiological studies, based on particular groups of in-line skaters, in order to describe them, to identify and quantify risk factors and to design preventive measures, and then to appraise their efficiency.