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Increased glomerular cell heparan sulfates in vitro by ciclosporin A: a Possible explanation of Its beneficial effect in idiopathic nephrotic syndrome

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Published in Nephron. 2001, vol. 88, no. 2, p. 156-62
Abstract In idiopathic nephrotic syndrome (INS), ciclosporin A (CsA) was shown to decrease proteinuria, an effect explained by its immunologic and hemodynamic actions. In order to determine whether CsA could have a direct action on glomerular cells, we studied the effect of CsA on glomerular cells in vitro, particularly on glycosaminoglcycans (GAG) and heparan sulfates (HS) which are decreased in INS patients.
Keywords AnimalsCells, CulturedCyclic AMP/metabolismCyclosporine/pharmacologyGlomerular Mesangium/cytology/drug effects/metabolismGlycosaminoglycans/metabolismHeparitin Sulfate/metabolismHumansImmunosuppressive Agents/pharmacologyKidney Glomerulus/cytology/drug effects/metabolismNephrotic Syndrome/drug therapyRatsRats, Sprague-Dawley
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PMID: 11399919
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Article (Published version) (263 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
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BIRMELE, Béatrice, DE AGOSTINI, Ariane, GIRARDIN, Eric. Increased glomerular cell heparan sulfates in vitro by ciclosporin A: a Possible explanation of Its beneficial effect in idiopathic nephrotic syndrome. In: Nephron, 2001, vol. 88, n° 2, p. 156-62. https://archive-ouverte.unige.ch/unige:72743

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Deposited on : 2015-05-21

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