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Scientific article
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Increased glomerular cell heparan sulfates in vitro by ciclosporin A: a Possible explanation of Its beneficial effect in idiopathic nephrotic syndrome

Published inThe Nephron journals, vol. 88, no. 2, p. 156-162
Publication date2001
Abstract

In idiopathic nephrotic syndrome (INS), ciclosporin A (CsA) was shown to decrease proteinuria, an effect explained by its immunologic and hemodynamic actions. In order to determine whether CsA could have a direct action on glomerular cells, we studied the effect of CsA on glomerular cells in vitro, particularly on glycosaminoglcycans (GAG) and heparan sulfates (HS) which are decreased in INS patients.

Keywords
  • Animals
  • Cells, Cultured
  • Cyclic AMP/metabolism
  • Cyclosporine/pharmacology
  • Glomerular Mesangium/cytology/drug effects/metabolism
  • Glycosaminoglycans/metabolism
  • Heparitin Sulfate/metabolism
  • Humans
  • Immunosuppressive Agents/pharmacology
  • Kidney Glomerulus/cytology/drug effects/metabolism
  • Nephrotic Syndrome/drug therapy
  • Rats
  • Rats, Sprague-Dawley
Citation (ISO format)
BIRMELE, Béatrice, DE AGOSTINI, Ariane, GIRARDIN, Eric. Increased glomerular cell heparan sulfates in vitro by ciclosporin A: a Possible explanation of Its beneficial effect in idiopathic nephrotic syndrome. In: The Nephron journals, 2001, vol. 88, n° 2, p. 156–162. doi: 10.1159/000045977
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Article (Published version)
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Identifiers
ISSN of the journal1660-8151
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