The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis

Perroud, Nader Ali; Rutembesa, Eugene; Giacobino, Ariane; Mutabaruka, Jean; Mutesa, Léon; Stenz, Ludwig; Malafosse, Alain; Karege, Félicien

doi:10.3109/15622975.2013.866693

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Title		The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis
Authors		Perroud, Nader Ali Rutembesa, Eugene Giacobino, Ariane Mutabaruka, Jean Mutesa, Léon Stenz, Ludwig Malafosse, Alain Karege, Félicien
Published in		The world journal of biological psychiatry. 2014, vol. 15, no. 4, p. 334-45
Abstract		Transmission of parental post-traumatic stress disorder (PTSD) to offspring might be explained by transmission of epigenetic processes such as methylation status of the glucocorticoid receptor (GR) gene (NR3C1).
Keywords		Adolescent — Adult — DNA Methylation/physiology — Depressive Disorder/etiology — Epigenesis, Genetic — Female — Genocide — Humans — Hydrocortisone/blood — Hypothalamo-Hypophyseal System/metabolism — Male — Mothers — Pituitary-Adrenal System/metabolism — Pregnancy — Prenatal Exposure Delayed Effects/metabolism — Receptors, Glucocorticoid/genetics/metabolism — Receptors, Mineralocorticoid/genetics/metabolism — Severity of Illness Index — Stress Disorders, Post-Traumatic/blood/etiology/metabolism
Identifiers		DOI: 10.3109/15622975.2013.866693 PMID: 24690014
Full text		Article (Published version) (275 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group		Groupe Giacobino Ariane (génétique) (923)
Citation (ISO format)		PERROUD, Nader Ali et al. The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis. In: The world journal of biological psychiatry, 2014, vol. 15, n° 4, p. 334-45. doi: 10.3109/15622975.2013.866693 https://archive-ouverte.unige.ch/unige:72646