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Modern anti-HIV therapy

Flepp, Markus
Schiffer, V.
Weber, R.
Published in Swiss Medical Weekly. 2001, vol. 131, no. 15-16, p. 207-213
Abstract Highly active antiretroviral therapies (HAART), usually consisting of two nucleoside reverse transcriptase inhibitors (NRTI) plus an HIV protease inhibitor (PI), have been widely used since 1996. They produce durable suppression of viral replication with undetectable plasma levels of HIV-RNA in more than half of patients. Immunity recovers, and morbidity and mortality fall by more than 80% [1, 2]. Treatment was thought to be particularly effective when started early; therefore, HAART was recommended for essentially all HIV-infected persons willing to commit themselves to lifelong therapy [3, 4]. Besides these successes, however, HAART also produces problems. HIV is not eradicated by present-day drugs, and patients often cannot comply with long-term combination treatment [5, 6]. Moreover, HAART causes unexpected and ill-understood side effects [7]. The dogma of earliest possible treatment has therefore come under attack. Ten principles governing anti-retroviral treatment are summarised in Table 1. Starting and maintaining HAART is complex. Within the last few years, the numbers of antiretrovirals, their known and potential interactions with each other and with non-HIV drugs, and the list of their side effects have all increased exponentially. As a rule a physician specialising in HIV care should be consulted whenever HAART is started or changed. It is his task to ensure that the treatment chosen is optimal for the particular patient.
Keywords Anti-HIV Agents/adverse effects/ therapeutic useAntiretroviral Therapy, Highly Active/adverse effectsDrug InteractionsHIV Infections/ drug therapyHumansLong-Term CarePatient ComplianceTreatment Outcome
PMID: 11400543
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FLEPP, Markus et al. Modern anti-HIV therapy. In: Swiss Medical Weekly, 2001, vol. 131, n° 15-16, p. 207-213. https://archive-ouverte.unige.ch/unige:7217

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Deposited on : 2010-06-21

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