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Title

Influence of previous exposure to antibiotic therapy on the susceptibility pattern of Pseudomonas aeruginosa bacteremic isolates
Authors
El Amari, E. B.
Chamot, E.
Auckenthaler, Raymond
Pechere, Jean-Claude
Van Delden, Christian
Published in Clinical infectious diseases. 2001, vol. 33, no. 11, p. 1859-1864
Abstract Many patients who present with Pseudomonas aeruginosa bacteremia have been previously exposed to antibiotics. To assess whether resistance of bacteremic strains to antipseudomonal antibiotics (piperacillin, ceftazidime, imipenem, ciprofloxacin, or aminoglycosides) is associated with previous exposure to these drugs, a case-control study including 267 cases of P. aeruginosa bacteremia was conducted. Twenty-five percent of the episodes had been preceded by the exposure to an antipseudomonal antibiotic. Eighty-one strains were resistant to at least 1 antibiotic; 186 were susceptible to all drugs. Via univariate analysis, the risks of resistance to ceftazidime and imipenem were found to be significantly associated with previous receipt of these agents. Using multivariate analysis, exposure to any antipseudomonal antibiotic as a monotherapy was found to be associated with an increased risk of subsequent resistance to itself (odds ratio, 2.5; P=.006). Therefore, clinicians should avoid readministering previously prescribed antibiotics when initiating empiric therapies for possible P. aeruginosa bacteremia, especially when they have been given as monotherapies.
Keywords Adolescent — Adult — Aged — Bacteremia/diagnosis/ microbiology — Case-Control Studies — Child — Child, Preschool — Disease Susceptibility — Drug Resistance, Bacterial — Female — Humans — Infant — Infant, Newborn — Male — Middle Aged — Pseudomonas Infections/diagnosis/ microbiology — Pseudomonas aeruginosa/ isolation & purification — Risk Factors
Identifiers
PMID: 11692297
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Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Citation
(ISO format) 		EL AMARI, E. B. et al. Influence of previous exposure to antibiotic therapy on the susceptibility pattern of Pseudomonas aeruginosa bacteremic isolates. In: Clinical infectious diseases, 2001, vol. 33, n° 11, p. 1859-1864. doi: 10.1086/324346 https://archive-ouverte.unige.ch/unige:7190

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Deposited on : 2010-06-21

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