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Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines

Cevey-Macherel, Manon
Bille, Jacques
Krahenbuhl, J. D.
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Published in European Journal of Pediatrics. 2009, vol. 168, no. 12, p. 1429-1436
Abstract Community-acquired pneumonia (CAP) is a major cause of death in developing countries and of morbidity in developed countries. The objective of the study was to define the causative agents among children hospitalized for CAP defined by WHO guidelines and to correlate etiology with clinical severity and surrogate markers. Investigations included an extensive etiological workup. A potential causative agent was detected in 86% of the 99 enrolled patients, with evidence of bacterial (53%), viral (67%), and mixed (33%) infections. Streptococcus pneumoniae was accounted for in 46% of CAP. Dehydration was the only clinical sign associated with bacterial pneumonia. CRP and PCT were significantly higher in bacterial infections. Increasing the number of diagnostic tests identifies potential causes of CAP in up to 86% of children, indicating a high prevalence of viruses and frequent co-infections. The high proportion of pneumococcal infections re-emphasizes the importance of pneumococcal immunization.
PMID: 19238436
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Research groups Centre de vaccinologie et d'immunologie néonatale (177)
Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile (183)
Groupe Laurent Kaiser (virologie clinique) (668)
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CEVEY-MACHEREL, Manon et al. Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines. In: European Journal of Pediatrics, 2009, vol. 168, n° 12, p. 1429-1436. https://archive-ouverte.unige.ch/unige:7138

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Deposited on : 2010-06-21

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