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Toward Supramolecular Ion Channels Formed by Oligonucleotide Analogs: Hydrophobic Guanine Dimers

Authors
Chen, Li
Moshiri, Sara T.
Published in Tetrahedron Letters. 1998, vol. 39, no. 22, p. 3627-3630
Abstract In this model study toward supramolecular channels formed by oligonucleotide analogs, we describe the synthesis of hydrophobic guanine dimers 1–4. We found that the solubility of guanine dimers 1 – 4 is significantly reduced compared to hydrophobic (iso)guanosine monomers and independent of the nature of substituents at the exocyclic amine. This indicates that the (deoxy)ribose is important to form soluble, ionophoric G-quartets.
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CHEN, Li et al. Toward Supramolecular Ion Channels Formed by Oligonucleotide Analogs: Hydrophobic Guanine Dimers. In: Tetrahedron Letters, 1998, vol. 39, n° 22, p. 3627-3630. https://archive-ouverte.unige.ch/unige:7000

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Deposited on : 2010-06-18

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