en
Scientific article
Letter
English

p-Octiphenyl β-Barrels with Ion Channel and Esterase Activity

Published inOrganic letters, vol. 3, no. 26, p. 4229-4232
Publication date2001
Abstract

Design, synthesis, and esterase and ion channel activity of a novel barrel-stave supramolecule with hydrophobic exterior and histidine-rich interior are reported. Voltage-dependent binding of pyrenyl-8-oxy-1,3,6-trisulfonates by histidines within p-octiphenyl beta-barrels (and not monomers) via ionic (and not hydrophobic) interactions (K(D), K(I), K(M) < 1 microM) is the basis for superb esterolytic proficiency up to (k(cat)/K(M))/k(uncat) = 9.6 x 10(5) in water and bilayer membranes. The conductance of labile ion channels formed in planar bilayer membranes is shown to be reduced by 8-hydroxypyrene-1,3,6-trisulfonate on the single- and multichannel level.

Citation (ISO format)
BAUMEISTER, Bodo, SAKAI, Naomi, MATILE, Stefan. p-Octiphenyl β-Barrels with Ion Channel and Esterase Activity. In: Organic letters, 2001, vol. 3, n° 26, p. 4229–4232. doi: 10.1021/ol016914n
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