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Scientific article
English

Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomes

Contributors

Reinders, Jon; Wulff, Brande B. H.; Mirouze, Marie; Marí-Ordóñez, Arturo; Dapp, Mélanie; Rozhon, Wilfried; Bucher, Etienne; Theiler, Gregory; Paszkowski, Jerzy

Published in

Genes & development, vol. 23, no. 8, p. 939-950

Publication date

2009

Abstract

Transgenerational epigenetic inheritance has been defined by the study of relatively few loci. We examined a population of recombinant inbred lines with epigenetically mosaic chromosomes consisting of wild-type and CG methylation-depleted segments (epiRILs). Surprisingly, transposons that were immobile in the parental lines displayed stochastic movement in 28% of the epiRILs. Although analysis after eight generations of inbreeding, supported by genome-wide DNA methylation profiling, identified recombined parental chromosomal segments, these were interspersed with unexpectedly high frequencies of nonparental methylation polymorphism. Hence, epigenetic inheritance in hybrids derived from parents with divergent epigenomes permits long-lasting epi-allelic interactions that violate Mendelian expectations. Such persistently "unstable" epigenetic states complicate linkage-based epigenomic mapping. Thus, future epigenomic analyses should consider possible genetic instabilities and alternative mapping strategies.

Keywords

  • Arabidopsis/genetics/metabolism
  • Arabidopsis Proteins/genetics
  • Chromosome Mapping
  • Chromosomes, Plant/genetics
  • DNA (Cytosine-5-)-Methyltransferase/genetics
  • DNA Methylation/genetics
  • DNA Transposable Elements/genetics
  • Epigenesis, Genetic/genetics
  • Genes, Plant/genetics
  • Genome, Plant/genetics
  • Genomic Instability/genetics
  • Inbreeding
  • Mosaicism
  • Phenotype
  • Recombination, Genetic

UNIGE affiliation entities

Citation (ISO format)

REINDERS, Jon et al. Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomes. In: Genes & development, 2009, vol. 23, n° 8, p. 939–950. doi: 10.1101/gad.524609

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0890-9369
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Technical informations

Creation

08/06/2010 11:35:00

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08/06/2010 11:35:00

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