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Scientific article
English

Low Temperature Grignard Reactions with Pure Mg Slurries. Trapping of Cyclopropylmethyl and Benzocyclobutenylmethyl Grignard Reagents with CO2

Published inHelvetica chimica acta, vol. 64, no. 8, p. 2606-2613
Publication date1981
Abstract

Cyclopropylmethyl bromide reacts readily at -75° with a Mg/THF slurry formed by evaporation of Mg in a rotating-solution reactor to yield after carbonation cyclopropyl acetic acid and 4-pentenoic acid in a ratio of 11:1. Addition of benzaldehyde to the Grignard solution again predominantly yields the addition product containing the cyclopropylmethyl unit. Using the same low temperature Grignard method, benzocyclobutenyl acetic acid is isolated upon carbonation of the Grignard reagent derived from the corresponding bromide, whereas under normal conditions o-vinylphenylacetic acid, the product corresponding to ring cleaved Grignard is obtained.

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Citation (ISO format)
KUNDIG, Ernst Peter, PERRET, Celia. Low Temperature <i>Grignard</i> Reactions with Pure Mg Slurries. Trapping of Cyclopropylmethyl and Benzocyclobutenylmethyl <i>Grignard</i> Reagents with CO<sub>2</sub>. In: Helvetica chimica acta, 1981, vol. 64, n° 8, p. 2606–2613. doi: 10.1002/hlca.19810640817
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ISSN of the journal0018-019X
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