• Home
  1. Home
  2. LTP promotes a selective long-term stabilization and clustering of dendritic spines
Scientific article
OA Policy
English

LTP promotes a selective long-term stabilization and clustering of dendritic spines

Contributors

De Roo, Mathias; Klauser, Paul; Muller, Dominique

Published in

PLoS biology, vol. 6, no. 9, e219

Publication date

2008

Abstract

Dendritic spines are the main postsynaptic site of excitatory contacts between neurons in the central nervous system. On cortical neurons, spines undergo a continuous turnover regulated by development and sensory activity. However, the functional implications of this synaptic remodeling for network properties remain currently unknown. Using repetitive confocal imaging on hippocampal organotypic cultures, we find that learning-related patterns of activity that induce long-term potentiation act as a selection mechanism for the stabilization and localization of spines. Through a lasting N-methyl-D-aspartate receptor and protein synthesis-dependent increase in protrusion growth and turnover, induction of plasticity promotes a pruning and replacement of nonactivated spines by new ones together with a selective stabilization of activated synapses. Furthermore, most newly formed spines preferentially grow in close proximity to activated synapses and become functional within 24 h, leading to a clustering of functional synapses. Our results indicate that synaptic remodeling associated with induction of long-term potentiation favors the selection of inputs showing spatiotemporal interactions on a given neuron.

Keywords

  • Dendritic Spines
  • Electrophysiology
  • Excitatory Postsynaptic Potentials
  • Hippocampus
  • Long-Term Potentiation
  • Neuronal Plasticity
  • Neurons
  • Pyramidal Cells
  • Rats
  • Synapses
  • Synaptic Transmission
  • Tissue Culture Techniques

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

DE ROO, Mathias, KLAUSER, Paul, MULLER, Dominique. LTP promotes a selective long-term stabilization and clustering of dendritic spines. In: PLoS biology, 2008, vol. 6, n° 9, p. e219. doi: 10.1371/journal.pbio.0060219

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://biology.plosjournals.org/archive/1544-9173/6/9/pdf/10.1371_journal.pbio.0060219-L.pdf

Journal ISSN

1544-9173
619views
510downloads

Technical informations

Creation

26/11/2008 15:15:00

First validation

26/11/2008 15:15:00

Update

14/03/2023 15:02:26

Status update

14/03/2023 15:02:26

Last indexation

29/10/2024 11:04:24
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated