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Scientific article
Open access
English

Nosocomial outbreak of multiple bloodborne viral infections

Published inThe Journal of infectious diseases, vol. 184, no. 3, p. 369-372
Publication date2001
Abstract

In resource-limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in approximately 400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission.

Keywords
  • Adult
  • Blood-Borne Pathogens
  • Child
  • Cross Infection/epidemiology
  • Disease Outbreaks
  • Genotype
  • HIV Infections/blood/diagnosis/epidemiology
  • HIV-1/classification/genetics/isolation & purification
  • Hepacivirus/genetics/isolation & purification
  • Hepatitis B/blood/diagnosis/epidemiology
  • Hepatitis B Antibodies/blood
  • Hepatitis C/blood/diagnosis/epidemiology
  • Hepatitis C Antibodies/blood
  • Humans
  • Libya/epidemiology/ethnology
  • Parents
  • Phylogeny
  • RNA, Viral/blood/isolation & purification
  • Switzerland
  • Viremia/diagnosis/epidemiology
Citation (ISO format)
YERLY FERRILLO, Sabine et al. Nosocomial outbreak of multiple bloodborne viral infections. In: The Journal of infectious diseases, 2001, vol. 184, n° 3, p. 369–372. doi: 10.1086/322036
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Article (Published version)
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Identifiers
ISSN of the journal0022-1899
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