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Nosocomial outbreak of multiple bloodborne viral infections

Burgisser, P
Published in The Journal of Infectious Diseases. 2001, vol. 184, no. 3, p. 369-72
Abstract In resource-limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in approximately 400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission.
Keywords AdultBlood-Borne PathogensChildCross Infection/epidemiologyDisease OutbreaksGenotypeHIV Infections/blood/diagnosis/epidemiologyHIV-1/classification/genetics/isolation & purificationHepacivirus/genetics/isolation & purificationHepatitis B/blood/diagnosis/epidemiologyHepatitis B Antibodies/bloodHepatitis C/blood/diagnosis/epidemiologyHepatitis C Antibodies/bloodHumansLibya/epidemiology/ethnologyParentsPhylogenyRNA, Viral/blood/isolation & purificationSwitzerlandViremia/diagnosis/epidemiology
PMID: 11443566
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Research groups Centre de Vaccinologie et d'Immunologie néonatale (177)
Groupe Posfay-Barbe Clara (pédiatrie générale) (853)
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YERLY FERRILLO, Sabine et al. Nosocomial outbreak of multiple bloodborne viral infections. In: The Journal of Infectious Diseases, 2001, vol. 184, n° 3, p. 369-72. https://archive-ouverte.unige.ch/unige:56144

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Deposited on : 2015-05-13

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