Nosocomial outbreak of multiple bloodborne viral infections

Yerly Ferrillo, Sabine; Quadri Defilippis, Rafael; Negro, Francesco; Posfay Barbe, Klara; Cheseaux, Jean-Jacques; Burgisser, P; Siegrist, Claire-Anne; Perrin, Luc

doi:10.1086/322036

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Title		Nosocomial outbreak of multiple bloodborne viral infections
Authors		Yerly Ferrillo, Sabine Quadri Defilippis, Rafael Negro, Francesco Posfay Barbe, Klara Cheseaux, Jean-Jacques Burgisser, P Siegrist, Claire-Anne Perrin, Luc
Published in		The Journal of infectious diseases. 2001, vol. 184, no. 3, p. 369-72
Abstract		In resource-limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in approximately 400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission.
Keywords		Adult — Blood-Borne Pathogens — Child — Cross Infection/epidemiology — Disease Outbreaks — Genotype — HIV Infections/blood/diagnosis/epidemiology — HIV-1/classification/genetics/isolation & purification — Hepacivirus/genetics/isolation & purification — Hepatitis B/blood/diagnosis/epidemiology — Hepatitis B Antibodies/blood — Hepatitis C/blood/diagnosis/epidemiology — Hepatitis C Antibodies/blood — Humans — Libya/epidemiology/ethnology — Parents — Phylogeny — RNA, Viral/blood/isolation & purification — Switzerland — Viremia/diagnosis/epidemiology
Identifiers		DOI: 10.1086/322036 PMID: 11443566
Full text		Article (Published version) (86 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		Centre de Vaccinologie et d'Immunologie néonatale (177) Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Citation (ISO format)		YERLY FERRILLO, Sabine et al. Nosocomial outbreak of multiple bloodborne viral infections. In: The Journal of infectious diseases, 2001, vol. 184, n° 3, p. 369-72. doi: 10.1086/322036 https://archive-ouverte.unige.ch/unige:56144