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Titles listT lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells
Titles listT lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells
Scientific Article - Review
unige:55984 
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T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells |
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| Published in | Pediatric Allergy and Immunology. 2002, vol. 13, no. 3, p. 162-71 | |
| Abstract | Although food hypersensitivity might be divided in IgE- and non-IgE mediated food allergy, there is a large body of evidence implicating T lymphocytes overall in the pathogenesis of food allergy. Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors (l-selectin, CCR7 and CXCR4) will help to initiate diapedesis of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. Food-specific memory T cells express various surface receptors such as the alpha4beta7-integrin, or the cutaneous lymphocyte antigen. It is speculated, that they might also express specific chemokine receptors (CCR4, CCR7 or CCR9). Organ-specific homing will be facilitated through the corresponding receptors (i.e. MAdCAM-1 in the gut, VCAM-1 or fibronectin in other mucosal organs, or E-selectin in the skin). Locally secreted chemokines might help to attract T cells through their corresponding chemokine receptors. Finally, potential T-cell directed therapeutic interventions (peptide-derived immunotherapy, DNA vaccination, or strategies preventing T cells from trafficking to target organs) are discussed. | |
| Keywords | Allergens — Cell Adhesion — Chemokines/metabolism — Child — Digestive System/immunology — Food Hypersensitivity/etiology/immunology/therapy — Humans — Immune Tolerance — Immunologic Memory — Immunotherapy — Integrins/metabolism — Models, Immunological — Peyer's Patches/immunology — Receptors, Chemokine/metabolism — T-Lymphocytes/immunology | |
| Identifiers | PMID: 12144637 | |
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| Research group | Pathogenèse et traitement des allergies alimentaires (191) | |
| Citation (ISO format) | EIGENMANN, Philippe. T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells. In: Pediatric allergy and immunology, 2002, vol. 13, n° 3, p. 162-71. doi: 10.1034/j.1399-3038.2002.01015.x https://archive-ouverte.unige.ch/unige:55984 |
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