Scientific article

T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells

Published inPediatric allergy and immunology, vol. 13, no. 3, p. 162-171
Publication date2002

Although food hypersensitivity might be divided in IgE- and non-IgE mediated food allergy, there is a large body of evidence implicating T lymphocytes overall in the pathogenesis of food allergy. Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors (l-selectin, CCR7 and CXCR4) will help to initiate diapedesis of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. Food-specific memory T cells express various surface receptors such as the alpha4beta7-integrin, or the cutaneous lymphocyte antigen. It is speculated, that they might also express specific chemokine receptors (CCR4, CCR7 or CCR9). Organ-specific homing will be facilitated through the corresponding receptors (i.e. MAdCAM-1 in the gut, VCAM-1 or fibronectin in other mucosal organs, or E-selectin in the skin). Locally secreted chemokines might help to attract T cells through their corresponding chemokine receptors. Finally, potential T-cell directed therapeutic interventions (peptide-derived immunotherapy, DNA vaccination, or strategies preventing T cells from trafficking to target organs) are discussed.

  • Allergens
  • Cell Adhesion
  • Chemokines/metabolism
  • Child
  • Digestive System/immunology
  • Food Hypersensitivity/etiology/immunology/therapy
  • Humans
  • Immune Tolerance
  • Immunologic Memory
  • Immunotherapy
  • Integrins/metabolism
  • Models, Immunological
  • Peyer's Patches/immunology
  • Receptors, Chemokine/metabolism
  • T-Lymphocytes/immunology
Citation (ISO format)
EIGENMANN, Philippe. T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells. In: Pediatric allergy and immunology, 2002, vol. 13, n° 3, p. 162–171. doi: 10.1034/j.1399-3038.2002.01015.x
Main files (1)
Article (Published version)
ISSN of the journal0905-6157

Technical informations

Creation04/23/2015 1:46:00 PM
First validation04/23/2015 1:46:00 PM
Update time03/14/2023 11:15:01 PM
Status update03/14/2023 11:15:01 PM
Last indexation01/16/2024 5:54:55 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack