UNIGE document Scientific Article - Review
previous document  unige:55984  next document
add to browser collection
Title

T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells

Author
Published in Pediatric Allergy and Immunology. 2002, vol. 13, no. 3, p. 162-71
Abstract Although food hypersensitivity might be divided in IgE- and non-IgE mediated food allergy, there is a large body of evidence implicating T lymphocytes overall in the pathogenesis of food allergy. Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors (l-selectin, CCR7 and CXCR4) will help to initiate diapedesis of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. Food-specific memory T cells express various surface receptors such as the alpha4beta7-integrin, or the cutaneous lymphocyte antigen. It is speculated, that they might also express specific chemokine receptors (CCR4, CCR7 or CCR9). Organ-specific homing will be facilitated through the corresponding receptors (i.e. MAdCAM-1 in the gut, VCAM-1 or fibronectin in other mucosal organs, or E-selectin in the skin). Locally secreted chemokines might help to attract T cells through their corresponding chemokine receptors. Finally, potential T-cell directed therapeutic interventions (peptide-derived immunotherapy, DNA vaccination, or strategies preventing T cells from trafficking to target organs) are discussed.
Keywords AllergensCell AdhesionChemokines/metabolismChildDigestive System/immunologyFood Hypersensitivity/etiology/immunology/therapyHumansImmune ToleranceImmunologic MemoryImmunotherapyIntegrins/metabolismModels, ImmunologicalPeyer's Patches/immunologyReceptors, Chemokine/metabolismT-Lymphocytes/immunology
Identifiers
PMID: 12144637
Full text
Article (Published version) (200 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Pathogenèse et traitement des allergies alimentaires (191)
Citation
(ISO format)
EIGENMANN, Philippe. T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells. In: Pediatric Allergy and Immunology, 2002, vol. 13, n° 3, p. 162-71. https://archive-ouverte.unige.ch/unige:55984

80 hits

0 download

Update

Deposited on : 2015-04-30

Export document
Format :
Citation style :