en
Scientific article
English

Nicotine gum treatment before smoking cessation: a randomized trial

Published inArchives of internal medicine, vol. 169, no. 11, p. 1028-1034
Publication date2009
Abstract

BACKGROUND: New ways of improving the efficacy of nicotine therapy need to be explored. We tested whether starting nicotine polacrilex gum treatment 4 weeks before the quit date improved smoking abstinence rates compared with starting treatment on the quit date. METHODS: An open randomized trial of 314 daily smokers (mean, 23.7 cigarettes/d) enrolled through the Internet and by physicians in Switzerland from November 2005 to January 2007. In the precessation treatment group, participants received nicotine polacrilex gum (4 mg, unflavored) by mail for 4 weeks before and 8 weeks after their target quit date, and they were instructed to decrease their cigarette consumption by half before quitting. In the usual care group, participants received the same nicotine gum for 8 weeks after their quit date and were instructed to quit abruptly. Instructions were limited to a booklet sent by mail and access to a smoking cessation Web site. Results are expressed as self-reported abstinence rates at the end of treatment and as biochemically verified smoking abstinence (cotinine plus carbon monoxide) after 12 months. RESULTS: Eight weeks after the target quit date, self-reported 4-week abstinence rates were 41.6% in the precessation treatment group and 44.4% in the usual care group (P =.61). One year after the target quit date, biochemically verified 4-week smoking abstinence rates were 20.8% in the precessation treatment group and 19.4% in the usual care group (P =.76). CONCLUSION: Starting nicotine gum treatment 4 weeks before the target quit date was no more effective than starting treatment on the quit date.

Keywords
  • Bupropion/therapeutic use
  • Chewing Gum
  • Humans
  • Nicotine/administration & dosage/analogs & derivatives
  • Polymethacrylic Acids/administration & dosage
  • Polyvinyls/administration & dosage
  • Smoking Cessation/methods
  • Weight Gain
NoteComment in: Sridharan L, Greenland P. Editorial policies and publication bias: the importance of negative studies. Arch Intern Med. 2009 Jun 8;169(11):1022-3.
Citation (ISO format)
ETTER, Jean-François et al. Nicotine gum treatment before smoking cessation: a randomized trial. In: Archives of internal medicine, 2009, vol. 169, n° 11, p. 1028–1034. doi: 10.1001/archinternmed.2009.12
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0003-9926
560views
2downloads

Technical informations

Creation03/25/2010 10:23:00 AM
First validation03/25/2010 10:23:00 AM
Update time03/14/2023 3:25:48 PM
Status update03/14/2023 3:25:48 PM
Last indexation01/15/2024 7:39:50 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack