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Title

Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses

Authors
Villiers, Marie-Bernadette
Villiers, Christian L
Published in Vaccine. 2004, vol. 23, no. 3, p. 329-35
Abstract Complement component C3, which plays an important role in both the innate and adaptative immune response, is present at low level in human infants. We show here that: (i) serum C3 amount is weak also in infant mice, (ii) these young animals fail to upregulate C3 to adult levels following tetanus toxoid immunization, (iii) neonatal macrophages have a limited capacity to synthesize C3 upon LPS exposure, (iv) conjugation of antigen to C3b significantly enhances antibody response elicited in 1-week-old mice--although it does not increase primary IgG response in adult mice. Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation.
Keywords Age FactorsAnimalsAnimals, NewbornCells, CulturedComplement C3b/biosynthesis/immunologyFemaleHumansImmunization ScheduleImmunoglobulin G/bloodLipopolysaccharides/pharmacologyMacrophages, Peritoneal/metabolismMaleMiceMice, Inbred BALB COvalbumin/immunologySpecies SpecificityTetanus Toxoid/immunologyUp-Regulation
Identifiers
PMID: 15530677
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Article (Published version) (130 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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PIHLGREN BOSCH, Maria Astrid Louise et al. Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses. In: Vaccine, 2004, vol. 23, n° 3, p. 329-35. https://archive-ouverte.unige.ch/unige:55491

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Deposited on : 2015-04-13

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