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Title

Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response

Authors
Efler, Sue M
Morris, Mary Lou
Al Adhami, Mohamed J
Cameron, D William
Cooper, Curtis L
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Published in Vaccine. 2004, vol. 23, no. 5, p. 615-22
Abstract We assessed the avidity maturation process elicited by human immunization with alum-adsorbed HBsAg alone or with a novel adjuvant containing CpG motifs (CpG 7909). Mean avidity indexes and distribution of low- and high-avidity anti-HBs indicated that avidity maturation essentially takes place late after priming. CpG 7909 markedly enhanced this affinity maturation process, increasing the pool of high-avidity antibodies. The influence of CpG 7909 was antigen-specific, isotype-specific and distinct from the influence on anti-HBs production, as avidity did not correlate with anti-HBs IgG titers. This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity.
Keywords Adjuvants, Immunologic/administration & dosageAdolescentAdultAntibody AffinityAntibody Specificity/immunologyB-LymphocytesFemaleHepatitis B Antibodies/immunologyHepatitis B Surface Antigens/immunologyHepatitis B Vaccines/administration & dosage/immunologyHumansImmunoglobulin G/blood/immunologyMaleOligodeoxyribonucleotides/administration & dosage
Identifiers
PMID: 15542181
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Article (Published version) (373 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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SIEGRIST, Claire-Anne et al. Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response. In: Vaccine, 2004, vol. 23, n° 5, p. 615-22. https://archive-ouverte.unige.ch/unige:55346

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Deposited on : 2015-04-09

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