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Title

Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeys

Authors
Walsh, Douglas S
Pichyangkul, Sathit
Gettayacamin, Montip
Tongtawe, Pongsri
Hansukjariya, Pranee
Kester, Kent E
Holland, Carolyn A
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Published in American Journal of Tropical Medicine and Hygiene. 2004, vol. 70, no. 5, p. 499-509
Abstract Malaria vaccine RTS,S combined with thrombospondin-related anonymous protein (TRAP) and formulated with AS02A (RTS,S+TRAP/AS02A) is safe and immunogenic in adult humans and rhesus monkeys (Macaca mulatta). Here, RTS,S+TRAP/AS02A was administered on a 0-, 1-, and 3-month schedule to three cohorts of infant monkeys, along with adult comparators. Cohort 1 evaluated 1/5, 1/2, and full adult doses, with the first dose administration at one month of age; cohort 2 monkeys received full adult doses, with the first dose administration at one versus three months of age; and, cohort 3 compared infants gestated in mothers with or without previous RTS,S/AS02A immunization. Immunization site reactogenicity was mild. Some infants, including the phosphate-buffered saline only recipient, developed transient iron-deficiency anemia, which is considered a result of repeated phlebotomies. All RTS,S+TRAP/AS02A regimens induced vigorous antibody responses that persisted through 12 weeks after the last vaccine dose. Modest lymphoproliferative and ELISPOT (interferon-gamma and interleukin-5) responses, particularly to TRAP, approximated adult comparators. RTS,S+TRAP/AS02A was safe and well tolerated. Vigorous antibody production and modest, selective cell-mediated immune responses suggest that RTS,S+TRAP/AS02A may be immunogenic in human infants.
Keywords Adjuvants, Immunologic/administration & dosageAnimalsAntibodies, Protozoan/bloodFemaleHepatitis B Surface Antigens/immunologyHumansImmunizationInterferon-gamma/biosynthesisInterleukin-5/biosynthesisLipid A/administration & dosage/analogs & derivativesLymphocyte ActivationMacaca mulattaMalaria Vaccines/administration & dosage/immunology/toxicityProtozoan Proteins/immunologySaponins/administration & dosageVaccines, Synthetic/immunology/toxicity
Identifiers
PMID: 15155981
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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(ISO format)
WALSH, Douglas S et al. Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeys. In: American Journal of Tropical Medicine and Hygiene, 2004, vol. 70, n° 5, p. 499-509. https://archive-ouverte.unige.ch/unige:55339

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Deposited on : 2015-04-09

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