en
Scientific article
Review
English

Proteomic analysis of human bile and potential applications for cancer diagnosis

Published inExpert review of proteomics, vol. 6, no. 3, p. 285-301
Publication date2009
Abstract

Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum. It has two major functions: first, it contains bile acids, which are critical for the digestion of fats, and second, it is an excretory pathway for many endogenous and exogenous compounds. Proteomic analysis of bile is particularly difficult since this fluid contains high concentrations of various substances that strongly interfere with protein separation and identification techniques. Furthermore, owing to its deep location in the body, bile must be collected by surgical or endoscopic procedures. However, as was speculated for other body fluids, bile appears to be a promising sample for the discovery of disease biomarkers leaking from proximal tissues: the liver, pancreas or biliary tree. The interest in clinical proteomics was demonstrated by two studies that identified in bile potential biomarkers for two deadly and difficult to diagnose neoplasms, pancreatic cancer and cholangiocarcinoma.

Keywords
  • Bile/metabolism
  • Biological Markers/analysis
  • Humans
  • Neoplasms/diagnosis
  • Proteome/analysis
  • Proteomics
Citation (ISO format)
FARINA, Annarita, DUMONCEAU, Jean-Marc, LESCUYER, Pierre. Proteomic analysis of human bile and potential applications for cancer diagnosis. In: Expert review of proteomics, 2009, vol. 6, n° 3, p. 285–301. doi: 10.1586/epr.09.12
Identifiers
ISSN of the journal1478-9450
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