Scientific article

Freely drawn single lipid nanotube patterns

Published inSoft matter, vol. 11, no. 10, p. 2029-2035
Publication date2015

LNTs are unique 3D structures made only of safe and abundant biomaterials by self-assembly. The current bottleneck for developing applications using LNTs is the lack of an easy technique to pattern them on substrates. We report a method to free-draw single lipid nanotube (LNT) patterns in any shape on surfaces with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) that takes an inverted hexagonal (HII) phase. We used pre-self-assembled LNTs or HII lipid blocks as a lipid reservoir from which new LNTs were pulled by applying a point load with a micromanipulator. The extreme simplicity of our technique originates from the fundamental nature of DOPE lipids that prefer a HII phase, while all the conventional approaches use PC lipids that form a lamellar phase. By adjusting the surface properties with polyelectrolyte multilayers, the created single LNT objects are able to remain adhered to the surface for over a week. Importantly, it could be shown that two vesicles loaded with caged fluorescent molecules were able to fuse well with a LNT, enabling diffusive transport of uncaged fluorescent molecules from one vesicle to the other.

Research group
Citation (ISO format)
SUGIHARA, Kaori, RUSTOM, Amin, SPATZ, Joachim P. Freely drawn single lipid nanotube patterns. In: Soft matter, 2015, vol. 11, n° 10, p. 2029–2035. doi: 10.1039/C5SM00043B
Main files (1)
Article (Published version)
ISSN of the journal1744-683X

Technical informations

Creation04/01/2015 8:27:00 AM
First validation04/01/2015 8:27:00 AM
Update time03/14/2023 11:06:36 PM
Status update03/14/2023 11:06:35 PM
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