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Scientific Article
unige:55061 
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Freely drawn single lipid nanotube patterns |
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| Authors | ||
| Published in | Soft Matter. 2015, vol. 11, no. 10, p. 2029-2035 | |
| Abstract | LNTs are unique 3D structures made only of safe and abundant biomaterials by self-assembly. The current bottleneck for developing applications using LNTs is the lack of an easy technique to pattern them on substrates. We report a method to free-draw single lipid nanotube (LNT) patterns in any shape on surfaces with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) that takes an inverted hexagonal (HII) phase. We used pre-self-assembled LNTs or HII lipid blocks as a lipid reservoir from which new LNTs were pulled by applying a point load with a micromanipulator. The extreme simplicity of our technique originates from the fundamental nature of DOPE lipids that prefer a HII phase, while all the conventional approaches use PC lipids that form a lamellar phase. By adjusting the surface properties with polyelectrolyte multilayers, the created single LNT objects are able to remain adhered to the surface for over a week. Importantly, it could be shown that two vesicles loaded with caged fluorescent molecules were able to fuse well with a LNT, enabling diffusive transport of uncaged fluorescent molecules from one vesicle to the other. | |
| Identifiers | DOI: 10.1039/C5SM00043B | |
| Full text |
Article (Published version) (2.5 MB) - Limited access to UNIGE Other version: http://xlink.rsc.org/?DOI=C5SM00043B |
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| Structures | ||
| Research group | Groupe Sugihara | |
| Citation (ISO format) | SUGIHARA, Kaori, RUSTOM, Amin, SPATZ, Joachim P. Freely drawn single lipid nanotube patterns. In: Soft Matter, 2015, vol. 11, n° 10, p. 2029-2035. https://archive-ouverte.unige.ch/unige:55061 |
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