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Title

Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample

Authors
Dehouck, P.
Vander Heyden, Y.
Smeyers-Verbeke, J.
Massart, D.L.
Crommen, J.
Hubert, J.
Marini, R.D.
Smeets, O.S.N.M.
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Published in Analytica Chimica Acta. 2003, vol. 481, no. 2, p. 261-272
Abstract The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of uncertainty have been proposed. They include: within-laboratory uncertainty, reproducibility uncertainty, bias-included uncertainty and absolute uncertainty. Here we consider the evaluation of the reproducibility uncertainty derived from the results obtained in an inter-laboratory experiment. Nine laboratories participated in an inter-laboratory study for the analysis of phenoxymethylpenicillin. The analyses consisted of a Karl–Fischer water determination, an acid–base titration to assay phenoxymethylpenicillin and a liquid chromatography (LC) method to determine 4-hydroxyphenoxymethylpenicillin and other impurities. The experimental set-up allowed to obtain for each determination s2 r and s2L as estimates of the repeatability variance (σ2 r ) and the between-laboratory variance (σ2L ), respectively. The reproducibility uncertainties for the different assays were then derived from these estimates.
Keywords UncertaintyCollaborative studyReproducibilityPhenoxymethylpenicillin
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DEHOUCK, P. et al. Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample. In: Analytica Chimica Acta, 2003, vol. 481, n° 2, p. 261-272. https://archive-ouverte.unige.ch/unige:5145

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Deposited on : 2010-02-09

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