en
Scientific article
English

Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample

Published inAnalytica chimica acta, vol. 481, no. 2, p. 261-272
Publication date2003
Abstract

The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of uncertainty have been proposed. They include: within-laboratory uncertainty, reproducibility uncertainty, bias-included uncertainty and absolute uncertainty. Here we consider the evaluation of the reproducibility uncertainty derived from the results obtained in an inter-laboratory experiment. Nine laboratories participated in an inter-laboratory study for the analysis of phenoxymethylpenicillin. The analyses consisted of a Karl–Fischer water determination, an acid–base titration to assay phenoxymethylpenicillin and a liquid chromatography (LC) method to determine 4-hydroxyphenoxymethylpenicillin and other impurities. The experimental set-up allowed to obtain for each determination s2 r and s2L as estimates of the repeatability variance (σ2 r ) and the between-laboratory variance (σ2L ), respectively. The reproducibility uncertainties for the different assays were then derived from these estimates.

Keywords
  • Uncertainty
  • Collaborative study
  • Reproducibility
  • Phenoxymethylpenicillin
Citation (ISO format)
DEHOUCK, P. et al. Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample. In: Analytica chimica acta, 2003, vol. 481, n° 2, p. 261–272. doi: 10.1016/S0003-2670(03)00079-5
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0003-2670
554views
0downloads

Technical informations

Creation02/09/2010 12:14:00 PM
First validation02/09/2010 12:14:00 PM
Update time03/14/2023 3:23:50 PM
Status update03/14/2023 3:23:50 PM
Last indexation01/15/2024 7:32:07 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack