Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample

Dehouck, P.; Vander Heyden, Y.; Smeyers-Verbeke, J.; Massart, D.L.; Crommen, J.; Hubert, J.; Marini, R.D.; Smeets, O.S.N.M.; Decristoforo, G.; Van de Wauw, W.; De Beer, J.; Quaglia, M.G.; Stella, Cinzia; Veuthey, Jean-Luc; Estevenon, O.; Van Schepdael, A.; Roets, E.; Hoogmartens, J.

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Title		Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample
Authors		Dehouck, P. Vander Heyden, Y. Smeyers-Verbeke, J. Massart, D.L. Crommen, J. Hubert, J. Marini, R.D. Smeets, O.S.N.M. Decristoforo, G. Van de Wauw, W. De Beer, J. Quaglia, M.G. Stella, Cinzia Veuthey, Jean-Luc Estevenon, O. Van Schepdael, A. Roets, E. Hoogmartens, J. show all authors [1 - 18]
Published in		Analytica Chimica Acta. 2003, vol. 481, no. 2, p. 261-272
Abstract		The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of uncertainty have been proposed. They include: within-laboratory uncertainty, reproducibility uncertainty, bias-included uncertainty and absolute uncertainty. Here we consider the evaluation of the reproducibility uncertainty derived from the results obtained in an inter-laboratory experiment. Nine laboratories participated in an inter-laboratory study for the analysis of phenoxymethylpenicillin. The analyses consisted of a Karl–Fischer water determination, an acid–base titration to assay phenoxymethylpenicillin and a liquid chromatography (LC) method to determine 4-hydroxyphenoxymethylpenicillin and other impurities. The experimental set-up allowed to obtain for each determination s2 r and s2L as estimates of the repeatability variance (σ2 r ) and the between-laboratory variance (σ2L ), respectively. The reproducibility uncertainties for the different assays were then derived from these estimates.
Keywords		Uncertainty — Collaborative study — Reproducibility — Phenoxymethylpenicillin
Identifiers		DOI: 10.1016/S0003-2670(03)00079-5
Full text		Article (Published version) (144 Kb) - Limited access to UNIGE
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Citation (ISO format)		DEHOUCK, P. et al. Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample. In: Analytica Chimica Acta, 2003, vol. 481, n° 2, p. 261-272. https://archive-ouverte.unige.ch/unige:5145