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Role of the serotonin receptor 6 in cortical circuit formation

Defense Thèse de doctorat : Univ. Genève et Lausanne, 2014 - Neur. 139 - 2014/11/05
Abstract The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of the 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of the 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires cyclin-dependent kinase 5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration.
Keywords 5-HT6 receptorMigrationSerotoninCortexCdk5
URN: urn:nbn:ch:unige-472670
Note Thèse en Neurosciences des universités de Genève et de Lausanne
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Research group Groupe Dayer Alexandre (Formation du circuit cortical) (875)
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JACOBSHAGEN, Moritz. Role of the serotonin receptor 6 in cortical circuit formation. Université de Genève. Thèse, 2014. https://archive-ouverte.unige.ch/unige:47267

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Deposited on : 2015-02-25

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