Article scientifique

Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation

Publié dansTransplantation, vol. 71, no. 11, p. 1601-1609
Date de publication2001

Attempts to induce tolerance though mixed hematopoietic chimerism in the discordant pig-to-baboon xenotransplantation model are sometimes complicated by a potentially fatal thrombotic microangiopathy in the recipient baboons. This state develops immediately after the infusion of porcine mobilized peripheral blood leukocytes, containing progenitor cells (PBPC). In our study, we examined the interaction of infused porcine PBPC with recipient platelets in vivo in baboons and investigated the underlying mechanisms using an in vitro model.

  • Animals
  • Antibodies, Monoclonal/therapeutic use
  • Hematopoietic Stem Cell Transplantation/adverse effects/mortality
  • L-Lactate Dehydrogenase/blood
  • P-Selectin/immunology
  • Papio
  • Peptides/therapeutic use
  • Platelet Aggregation/drug effects
  • Platelet Aggregation Inhibitors/therapeutic use
  • Swine
  • Thrombocytopenia/etiology
  • Thrombosis/etiology/physiopathology
  • Transplantation, Heterologous/adverse effects/mortality
Citation (format ISO)
ALWAYN, I P et al. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. In: Transplantation, 2001, vol. 71, n° 11, p. 1601–1609.
Fichiers principaux (1)
Article (Published version)
ISSN du journal0041-1337

Informations techniques

Création17/02/2015 15:26:00
Première validation17/02/2015 15:26:00
Heure de mise à jour14/03/2023 22:51:28
Changement de statut14/03/2023 22:51:27
Dernière indexation18/10/2023 22:03:13
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