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Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation

Alwayn, I P
Appel, J Z (3rd)
Goepfert, C
Csizmadia, E
Correa, L
Harper, D
Kitamura, H
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Published in Transplantation. 2001, vol. 71, no. 11, p. 1601-9
Abstract Attempts to induce tolerance though mixed hematopoietic chimerism in the discordant pig-to-baboon xenotransplantation model are sometimes complicated by a potentially fatal thrombotic microangiopathy in the recipient baboons. This state develops immediately after the infusion of porcine mobilized peripheral blood leukocytes, containing progenitor cells (PBPC). In our study, we examined the interaction of infused porcine PBPC with recipient platelets in vivo in baboons and investigated the underlying mechanisms using an in vitro model.
Keywords AnimalsAntibodies, Monoclonal/therapeutic useHematopoietic Stem Cell Transplantation/adverse effects/mortalityL-Lactate Dehydrogenase/bloodP-Selectin/immunologyPapioPeptides/therapeutic usePlatelet Aggregation/drug effectsPlatelet Aggregation Inhibitors/therapeutic useSwineThrombocytopenia/etiologyThrombosis/etiology/physiopathologyTransplantation, Heterologous/adverse effects/mortality
PMID: 11435972
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Research group Cultures cellulaires et transplantations (519)
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ALWAYN, I P et al. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. In: Transplantation, 2001, vol. 71, n° 11, p. 1601-9. https://archive-ouverte.unige.ch/unige:46855

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Deposited on : 2015-02-19

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