Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation

Alwayn, I P; Buehler, Leo Hans; Appel, J Z (3rd); Goepfert, C; Csizmadia, E; Correa, L; Harper, D; Kitamura, H; Down, J; Awwad, M; Sackstein, R; Cooper, D K; Robson, S C

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation
Authors		Alwayn, I P Buehler, Leo Hans Appel, J Z (3rd) Goepfert, C Csizmadia, E Correa, L Harper, D Kitamura, H Down, J Awwad, M Sackstein, R Cooper, D K Robson, S C show all authors [1 - 13]
Published in		Transplantation. 2001, vol. 71, no. 11, p. 1601-9
Abstract		Attempts to induce tolerance though mixed hematopoietic chimerism in the discordant pig-to-baboon xenotransplantation model are sometimes complicated by a potentially fatal thrombotic microangiopathy in the recipient baboons. This state develops immediately after the infusion of porcine mobilized peripheral blood leukocytes, containing progenitor cells (PBPC). In our study, we examined the interaction of infused porcine PBPC with recipient platelets in vivo in baboons and investigated the underlying mechanisms using an in vitro model.
Keywords		Animals — Antibodies, Monoclonal/therapeutic use — Hematopoietic Stem Cell Transplantation/adverse effects/mortality — L-Lactate Dehydrogenase/blood — P-Selectin/immunology — Papio — Peptides/therapeutic use — Platelet Aggregation/drug effects — Platelet Aggregation Inhibitors/therapeutic use — Swine — Thrombocytopenia/etiology — Thrombosis/etiology/physiopathology — Transplantation, Heterologous/adverse effects/mortality
Identifiers		PMID: 11435972
Full text		Article (Published version) (1.4 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group		Cultures cellulaires et transplantations (519)
Citation (ISO format)		ALWAYN, I P et al. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. In: Transplantation, 2001, vol. 71, n° 11, p. 1601-9. https://archive-ouverte.unige.ch/unige:46855