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Article scientifique
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Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation

Publié dansTransplantation, vol. 71, no. 11, p. 1601-1609
Date de publication2001
Résumé

Attempts to induce tolerance though mixed hematopoietic chimerism in the discordant pig-to-baboon xenotransplantation model are sometimes complicated by a potentially fatal thrombotic microangiopathy in the recipient baboons. This state develops immediately after the infusion of porcine mobilized peripheral blood leukocytes, containing progenitor cells (PBPC). In our study, we examined the interaction of infused porcine PBPC with recipient platelets in vivo in baboons and investigated the underlying mechanisms using an in vitro model.

Mots-clés
  • Animals
  • Antibodies, Monoclonal/therapeutic use
  • Hematopoietic Stem Cell Transplantation/adverse effects/mortality
  • L-Lactate Dehydrogenase/blood
  • P-Selectin/immunology
  • Papio
  • Peptides/therapeutic use
  • Platelet Aggregation/drug effects
  • Platelet Aggregation Inhibitors/therapeutic use
  • Swine
  • Thrombocytopenia/etiology
  • Thrombosis/etiology/physiopathology
  • Transplantation, Heterologous/adverse effects/mortality
Citation (format ISO)
ALWAYN, I P et al. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. In: Transplantation, 2001, vol. 71, n° 11, p. 1601–1609.
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Article (Published version)
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Identifiants
ISSN du journal0041-1337
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