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Scientific article
English

Stepping up versus standard doses of erythropoietin in preterm infants: a randomized controlled trial

Published inPediatric hematology and oncology, vol. 22, no. 8, p. 667-678
Publication date2005
Abstract

In this study, it is hypothesized that a planned increase in the dose of recombinant human erythropoietin (rh-EPO) can prevent transfusion in very low birth weight infants. Two different regimens of rh-EPO were administrated, one consisting in increasing dosage up to 5000 U/kg/wk, according to the individual reticulocytes response, and the second in a standard therapy of 1250 U/kg/wk. Fifty-one infants participated. Despite a significant higher reticulocytosis, the study was prematurely terminated due to the results of an interim analysis showing that transfusion was not avoided by increasing the rh-EPO. No significant differences were found between the two regimens concerning transfusion rate, volume transfused, gain in weight, and adverse effects. Progressive titration of rh-EPO to improve the biological response does not leave premature infants free of transfusion.

Keywords
  • Birth Weight
  • Blood Transfusion/adverse effects
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Erythropoietin/administration & dosage
  • Female
  • Hematologic Tests
  • Humans
  • Infant
  • Male
  • Recombinant Proteins/administration & dosage
  • Reticulocyte Count
  • Reticulocytes/drug effects/metabolism
  • Reticulocytosis/drug effects
  • Retrospective Studies
  • Survival Analysis
  • Treatment Outcome
Citation (ISO format)
GUMY PAUSE, Fabienne et al. Stepping up versus standard doses of erythropoietin in preterm infants: a randomized controlled trial. In: Pediatric hematology and oncology, 2005, vol. 22, n° 8, p. 667–678. doi: 10.1080/08880010500278715
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0888-0018
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