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Title

Stepping up versus standard doses of erythropoietin in preterm infants: a randomized controlled trial

Authors
Cingria, Laurence
Published in Pediatric Hematology & Oncology. 2005, vol. 22, no. 8, p. 667-78
Abstract In this study, it is hypothesized that a planned increase in the dose of recombinant human erythropoietin (rh-EPO) can prevent transfusion in very low birth weight infants. Two different regimens of rh-EPO were administrated, one consisting in increasing dosage up to 5000 U/kg/wk, according to the individual reticulocytes response, and the second in a standard therapy of 1250 U/kg/wk. Fifty-one infants participated. Despite a significant higher reticulocytosis, the study was prematurely terminated due to the results of an interim analysis showing that transfusion was not avoided by increasing the rh-EPO. No significant differences were found between the two regimens concerning transfusion rate, volume transfused, gain in weight, and adverse effects. Progressive titration of rh-EPO to improve the biological response does not leave premature infants free of transfusion.
Keywords Birth WeightBlood Transfusion/adverse effectsDose-Response Relationship, DrugDouble-Blind MethodErythropoietin/administration & dosageFemaleHematologic TestsHumansInfantMaleRecombinant Proteins/administration & dosageReticulocyte CountReticulocytes/drug effects/metabolismReticulocytosis/drug effectsRetrospective StudiesSurvival AnalysisTreatment Outcome
Identifiers
PMID: 16251172
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GUMY PAUSE, Fabienne et al. Stepping up versus standard doses of erythropoietin in preterm infants: a randomized controlled trial. In: Pediatric Hematology & Oncology, 2005, vol. 22, n° 8, p. 667-78. https://archive-ouverte.unige.ch/unige:46642

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Deposited on : 2015-02-12

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