UNIGE document Scientific Article - Review
previous document  unige:45239  next document
add to browser collection
Title

Bioartificial organ grafts: a view at the beginning of the third millennium

Authors
Hunkeler, D
Rajotte, R
Grey, D
Skjak-Break, G
Korbutt, G
Gill, R
Published in Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 2003, vol. 31, no. 4, p. 365-82
Abstract An immunoisolated collection of cells, which communicate and exchange essential factors, co-stimulatory hormones, as well as providing immunoprotection and immunomodulation, can be prepared, given existing scientific and medical know-how, within two decades. These "Bioartificial Organ Grafts" have advantages relative to isolated cell therapies, including beta-cell encapsulation for diabetes treatment, and xenotransplantation, which has a de facto moratorium. This paper documents that the majority of the research for the bioartificial organ grafts has been concluded, with the remaining hurdles minimum in comparison. The use of co-encapsulation and the induction of local immune-privilege will provide a more sensitive humoral hormonal response and graft survival, without systemic immunosuppression. A call for the staged implementation of bioartificial organ grafts, based on the best available medical practice, materials, tissue and technology available, is advocated. The implementation of bioartificial organ grafts can begin within the next two years, based on allografts succeeded by genetically modified human tissue, without the need to pass through a xenograft stage.
Keywords Bioartificial Organs/trendsCell TransplantationDiabetes Mellitus/therapyGenetic TherapyHumansTransplantation, HeterologousTransplantation, Homologous
Identifiers
PMID: 14672414
Full text
Article (Published version) (1.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Chirurgie viscérale (104)
Citation
(ISO format)
HUNKELER, D et al. Bioartificial organ grafts: a view at the beginning of the third millennium. In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 2003, vol. 31, n° 4, p. 365-82. https://archive-ouverte.unige.ch/unige:45239

145 hits

0 download

Update

Deposited on : 2015-01-14

Export document
Format :
Citation style :