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Combined antiviral-immunosuppressive treatment in human T-lymphotrophic virus 1-Sjögren-associated myelopathy

Published in Archives of neurology. 2006, vol. 63, no. 9, p. 1318-20
Abstract In several studies, antiretroviral drugs (principally zidovudine) have been used with success in the treatment of myelopathy associated with human T-lymphotrophic virus 1 (HTLV-1) (tropical spastic paraparesis-HTLV-1-associated myelopathy). The retrovirus HTLV-1 has been implicated as a causative agent of Sjögren syndrome (SS) in clinical reports and murine experiments. Moreover, a recognized complication of primary SS is a myelopathy, which has been shown in case reports to respond to immunosuppressive treatment.
Keywords Adenine/analogs & derivatives/therapeutic useAntiviral Agents/therapeutic useDrug Therapy, CombinationFemaleHTLV-I Infections/complications/drug therapy/radiotherapyHumansImmunosuppressive Agents/therapeutic useLamivudine/therapeutic useMagnetic Resonance Imaging/methodsMethylprednisolone/therapeutic useMiddle AgedOrganophosphonates/therapeutic usePrednisone/therapeutic useSjogren's Syndrome/complications/drug therapy/radiography
PMID: 16966512
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POT, Caroline et al. Combined antiviral-immunosuppressive treatment in human T-lymphotrophic virus 1-Sjögren-associated myelopathy. In: Archives of neurology, 2006, vol. 63, n° 9, p. 1318-20. doi: 10.1001/archneur.63.9.1318 https://archive-ouverte.unige.ch/unige:44610

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Deposited on : 2015-01-07

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