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Scientific article
Open access
English

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

Published inAntioxidants & redox signaling, vol. 18, no. 6, p. 630-641
Publication date2013
Abstract

Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes. Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in a mouse myocardial ischemia/reperfusion model. In vivo and ex vivo mouse myocardial ischemia/reperfusion procedures were performed.

Keywords
  • Acrylamides/administration & dosage
  • Animals
  • Chemokine CXCL2/metabolism
  • Humans
  • Male
  • Mice
  • Myocardial Infarction/drug therapy/enzymology/pathology
  • Myocardial Reperfusion Injury/drug therapy/pathology
  • NAD/biosynthesis
  • Neutrophil Infiltration/drug effects
  • Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors/metabolism
  • Oxidative Stress/drug effects
  • Piperidines/administration & dosage
  • Reactive Oxygen Species/metabolism
  • Signal Transduction
Citation (ISO format)
MONTECUCCO, Fabrizio et al. Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. In: Antioxidants & redox signaling, 2013, vol. 18, n° 6, p. 630–641. doi: 10.1089/ars.2011.4487
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1523-0864
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723downloads

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