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Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction |
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Published in | Antioxidants & Redox Signaling. 2013, vol. 18, no. 6, p. 630-41 | |
Abstract | Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes. Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in a mouse myocardial ischemia/reperfusion model. In vivo and ex vivo mouse myocardial ischemia/reperfusion procedures were performed. | |
Keywords | Acrylamides/administration & dosage — Animals — Chemokine CXCL2/metabolism — Humans — Male — Mice — Myocardial Infarction/drug therapy/enzymology/pathology — Myocardial Reperfusion Injury/drug therapy/pathology — NAD/biosynthesis — Neutrophil Infiltration/drug effects — Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors/metabolism — Oxidative Stress/drug effects — Piperidines/administration & dosage — Reactive Oxygen Species/metabolism — Signal Transduction | |
Identifiers | PMID: 22452634 | |
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Research groups | Chimie et protéomique clinique (270) Epidémiologie clinique (115) L'athérosclérose et ses complications cliniques (591) | |
Citation (ISO format) | MONTECUCCO, Fabrizio et al. Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. In: Antioxidants & redox signaling, 2013, vol. 18, n° 6, p. 630-41. doi: 10.1089/ars.2011.4487 https://archive-ouverte.unige.ch/unige:42482 |