Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

Montecucco, Fabrizio; Bauer, Inga; Braunersreuther, Vincent; Bruzzone, Santina; Akhmedov, Alexander; Lüscher, Thomas F; Speer, Timo; Poggi, Alessandro; Mannino, Elena; Pelli, Graziano; Galan, Katia; Bertolotto, Maria; Lenglet, Sébastien; Garuti, Anna; Montessuit, Christophe Albert; Lerch, René; Pellieux, Corinne; Vuilleumier, Nicolas; Dallegri, Franco; Mage, Jacqueline; Sebastian, Carlos; Mostoslavsky, Raul; Gayet-Ageron, Angèle; Patrone, Franco; Mach, François; Nencioni, Alessio

doi:10.1089/ars.2011.4487

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Title		Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction
Authors		Montecucco, Fabrizio Bauer, Inga Braunersreuther, Vincent Bruzzone, Santina Akhmedov, Alexander Lüscher, Thomas F Speer, Timo Poggi, Alessandro Mannino, Elena Pelli, Graziano Galan, Katia Bertolotto, Maria Lenglet, Sébastien Garuti, Anna Montessuit, Christophe Albert Lerch, René Pellieux, Corinne Vuilleumier, Nicolas Dallegri, Franco Mage, Jacqueline Sebastian, Carlos Mostoslavsky, Raul Gayet-Ageron, Angèle Patrone, Franco Mach, François Nencioni, Alessio show all authors [1 - 26]
Published in		Antioxidants & Redox Signaling. 2013, vol. 18, no. 6, p. 630-41
Abstract		Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes. Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in a mouse myocardial ischemia/reperfusion model. In vivo and ex vivo mouse myocardial ischemia/reperfusion procedures were performed.
Keywords		Acrylamides/administration & dosage — Animals — Chemokine CXCL2/metabolism — Humans — Male — Mice — Myocardial Infarction/drug therapy/enzymology/pathology — Myocardial Reperfusion Injury/drug therapy/pathology — NAD/biosynthesis — Neutrophil Infiltration/drug effects — Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors/metabolism — Oxidative Stress/drug effects — Piperidines/administration & dosage — Reactive Oxygen Species/metabolism — Signal Transduction
Identifiers		DOI: 10.1089/ars.2011.4487 PMID: 22452634
Full text		Article (Published version) (885 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de médecine légale
Research groups		Chimie et protéomique clinique (270) Epidémiologie clinique (115) L'athérosclérose et ses complications cliniques (591)
Citation (ISO format)		MONTECUCCO, Fabrizio et al. Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. In: Antioxidants & redox signaling, 2013, vol. 18, n° 6, p. 630-41. doi: 10.1089/ars.2011.4487 https://archive-ouverte.unige.ch/unige:42482