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Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

Bauer, Inga
Bruzzone, Santina
Akhmedov, Alexander
Lüscher, Thomas F
Speer, Timo
Poggi, Alessandro
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Published in Antioxidants & Redox Signaling. 2013, vol. 18, no. 6, p. 630-41
Abstract Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes. Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in a mouse myocardial ischemia/reperfusion model. In vivo and ex vivo mouse myocardial ischemia/reperfusion procedures were performed.
Keywords Acrylamides/administration & dosageAnimalsChemokine CXCL2/metabolismHumansMaleMiceMyocardial Infarction/drug therapy/enzymology/pathologyMyocardial Reperfusion Injury/drug therapy/pathologyNAD/biosynthesisNeutrophil Infiltration/drug effectsNicotinamide Phosphoribosyltransferase/antagonists & inhibitors/metabolismOxidative Stress/drug effectsPiperidines/administration & dosageReactive Oxygen Species/metabolismSignal Transduction
PMID: 22452634
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Article (Published version) (885 Kb) - public document Free access
Research groups Chimie et protéomique clinique (270)
Epidémiologie clinique (115)
L'athérosclérose et ses complications cliniques (591)
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MONTECUCCO, Fabrizio et al. Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. In: Antioxidants & redox signaling, 2013, vol. 18, n° 6, p. 630-41. doi: 10.1089/ars.2011.4487 https://archive-ouverte.unige.ch/unige:42482

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Deposited on : 2014-12-04

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