Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition

Gambino, Frédéric; Holtmaat, Antonius

doi:10.1016/j.neuron.2012.05.020

Scientific article

English

Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition

Contributors

Gambino, Frédéric; Holtmaat, Antonius

Published in

Neuron, vol. 75, no. 3, p. 490-502

Publication date

2012

Abstract

Functional maps in the cerebral cortex reorganize in response to changes in experience, but the synaptic underpinnings remain uncertain. Here, we demonstrate that layer (L) 2/3 pyramidal cell synapses in mouse barrel cortex can be potentiated upon pairing of whisker-evoked postsynaptic potentials (PSPs) with action potentials (APs). This spike-timing-dependent long-term potentiation (STD-LTP) was only effective for PSPs evoked by deflections of a whisker in the neuron's receptive field center, and not its surround. Trimming of all except two whiskers rapidly opened the possibility to drive STD-LTP by the spared surround whisker. This facilitated STD-LTP was associated with a strong decrease in the surrounding whisker-evoked inhibitory conductance and partially occluded picrotoxin-mediated LTP facilitation. Taken together, our data demonstrate that sensory deprivation-mediated disinhibition facilitates STD-LTP from the sensory surround, which may promote correlation- and experience-dependent expansion of receptive fields.

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

UNIGE research groups

Les circuits neuronaux dans le néocortex des mammifères (855)

Funding

Citation (ISO format)

GAMBINO, Frédéric, HOLTMAAT, Antonius. Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition. In: Neuron, 2012, vol. 75, n° 3, p. 490–502. doi: 10.1016/j.neuron.2012.05.020

Article (Accepted version)

Identifiers

PID : unige:42006
DOI : 10.1016/j.neuron.2012.05.020
PMID : 22884332

Additional URL for this publication

http://linkinghub.elsevier.com/retrieve/pii/S0896627312004862

Journal ISSN

0896-6273

614views

3downloads

Creation

19/11/2014 13:29:00

First validation

19/11/2014 13:29:00

Update

05/08/2025 13:28:58

Status update

05/08/2025 13:28:58

Last indexation

05/08/2025 13:29:00

Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Funding

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation