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Title

Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition

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Published in Neuron. 2012, vol. 75, no. 3, p. 490-502
Abstract Functional maps in the cerebral cortex reorganize in response to changes in experience, but the synaptic underpinnings remain uncertain. Here, we demonstrate that layer (L) 2/3 pyramidal cell synapses in mouse barrel cortex can be potentiated upon pairing of whisker-evoked postsynaptic potentials (PSPs) with action potentials (APs). This spike-timing-dependent long-term potentiation (STD-LTP) was only effective for PSPs evoked by deflections of a whisker in the neuron's receptive field center, and not its surround. Trimming of all except two whiskers rapidly opened the possibility to drive STD-LTP by the spared surround whisker. This facilitated STD-LTP was associated with a strong decrease in the surrounding whisker-evoked inhibitory conductance and partially occluded picrotoxin-mediated LTP facilitation. Taken together, our data demonstrate that sensory deprivation-mediated disinhibition facilitates STD-LTP from the sensory surround, which may promote correlation- and experience-dependent expansion of receptive fields.
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PMID: 22884332
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Research group Les circuits neuronaux dans le néocortex des mammifères (855)
Projects FNS: 3100AO-120685; CRSI33- 127289
EMBO, ALTF 226-2010
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(ISO format)
GAMBINO, Frédéric, HOLTMAAT, Anthony. Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition. In: Neuron, 2012, vol. 75, n° 3, p. 490-502. https://archive-ouverte.unige.ch/unige:42006

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Deposited on : 2014-11-19

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