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Adrenomedullin: a vasodilator to treat sepsis?

Published in Critical Care. 2014, vol. 18, no. 3, p. 152
Abstract Adrenomedullin is a vasodilatory polypeptide with pleiotropic effects secreted by various organs. Adrenomedullin is produced first as a prepropeptide, and then cleaved into mature adrenomedullin and mid-regional proadrenomedullin. Whereas levels of the latter have been shown to correlate with severity of sepsis and carry prognostic value, adrenomedullin plays a role in vascular tone homeostasis. In the previous issue of Critical Care, the infusion of exogenous adrenomedullin is suggested to protect against increased lung endothelial permeability and end-organ dysfunction in a model of pneumococcal pneumonia in mechanically ventilated mice, possibly by stabilizing vascular endothelia. Since adrenomedullin is a strong vasodilatory molecule, further studies are needed to evaluate its potential as a future treatment of sepsis.
PMID: 25041977
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Research group Groupe Pugin Jérôme (Soins intensifs) (587)
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PUGIN, Jérôme. Adrenomedullin: a vasodilator to treat sepsis?. In: Critical Care, 2014, vol. 18, n° 3, p. 152. https://archive-ouverte.unige.ch/unige:41700

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Deposited on : 2014-11-12

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