UNIGE document Scientific Article - Comment
previous document  unige:41700  next document
add to browser collection
Title

Adrenomedullin: a vasodilator to treat sepsis?

Author
Published in Critical Care. 2014, vol. 18, no. 3, p. 152
Abstract Adrenomedullin is a vasodilatory polypeptide with pleiotropic effects secreted by various organs. Adrenomedullin is produced first as a prepropeptide, and then cleaved into mature adrenomedullin and mid-regional proadrenomedullin. Whereas levels of the latter have been shown to correlate with severity of sepsis and carry prognostic value, adrenomedullin plays a role in vascular tone homeostasis. In the previous issue of Critical Care, the infusion of exogenous adrenomedullin is suggested to protect against increased lung endothelial permeability and end-organ dysfunction in a model of pneumococcal pneumonia in mechanically ventilated mice, possibly by stabilizing vascular endothelia. Since adrenomedullin is a strong vasodilatory molecule, further studies are needed to evaluate its potential as a future treatment of sepsis.
Identifiers
PMID: 25041977
Full text
Article (Published version) (143 Kb) - public document Free access
Structures
Research group Groupe Pugin Jérôme (Soins intensifs) (587)
Citation
(ISO format)
PUGIN, Jérôme. Adrenomedullin: a vasodilator to treat sepsis?. In: Critical Care, 2014, vol. 18, n° 3, p. 152. https://archive-ouverte.unige.ch/unige:41700

206 hits

51 downloads

Update

Deposited on : 2014-11-12

Export document
Format :
Citation style :