Article (Published version) (143 Kb) - Free access
Adrenomedullin: a vasodilator to treat sepsis?
|Published in||Critical Care. 2014, vol. 18, no. 3, p. 152|
|Abstract||Adrenomedullin is a vasodilatory polypeptide with pleiotropic effects secreted by various organs. Adrenomedullin is produced first as a prepropeptide, and then cleaved into mature adrenomedullin and mid-regional proadrenomedullin. Whereas levels of the latter have been shown to correlate with severity of sepsis and carry prognostic value, adrenomedullin plays a role in vascular tone homeostasis. In the previous issue of Critical Care, the infusion of exogenous adrenomedullin is suggested to protect against increased lung endothelial permeability and end-organ dysfunction in a model of pneumococcal pneumonia in mechanically ventilated mice, possibly by stabilizing vascular endothelia. Since adrenomedullin is a strong vasodilatory molecule, further studies are needed to evaluate its potential as a future treatment of sepsis.|
|Research group||Groupe Pugin Jérôme (Soins intensifs) (587)|
|PUGIN, Jérôme. Adrenomedullin: a vasodilator to treat sepsis?. In: Critical Care, 2014, vol. 18, n° 3, p. 152. https://archive-ouverte.unige.ch/unige:41700|