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Adrenomedullin: a vasodilator to treat sepsis?

ContributorsPugin, Jérôme
Published inCritical care, vol. 18, no. 3, 152
Publication date2014
Abstract

Adrenomedullin is a vasodilatory polypeptide with pleiotropic effects secreted by various organs. Adrenomedullin is produced first as a prepropeptide, and then cleaved into mature adrenomedullin and mid-regional proadrenomedullin. Whereas levels of the latter have been shown to correlate with severity of sepsis and carry prognostic value, adrenomedullin plays a role in vascular tone homeostasis. In the previous issue of Critical Care, the infusion of exogenous adrenomedullin is suggested to protect against increased lung endothelial permeability and end-organ dysfunction in a model of pneumococcal pneumonia in mechanically ventilated mice, possibly by stabilizing vascular endothelia. Since adrenomedullin is a strong vasodilatory molecule, further studies are needed to evaluate its potential as a future treatment of sepsis.

Citation (ISO format)
PUGIN, Jérôme. Adrenomedullin: a vasodilator to treat sepsis? In: Critical care, 2014, vol. 18, n° 3, p. 152. doi: 10.1186/cc13924
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ISSN of the journal1364-8535
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Technical informations

Creation09/17/2014 11:15:00 AM
First validation09/17/2014 11:15:00 AM
Update time03/14/2023 10:14:12 PM
Status update03/14/2023 10:14:12 PM
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