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New concepts in organ preservation

Nydegger, U E
Carrel, T
Mohacsi, P
Published in Transplant Immunology. 2002, vol. 9, no. 2-4, p. 215-25
Abstract Organ preservation between donor and recipient is an important link in a chain that ultimately should lead to long term survival of the recipient thanks to a well-preserved, functionally intact organ. The period of organ ischaemia outside the body is subject to a number of biochemical stress factors which become known in more detail as knowledge on biochemical and immunological mechanisms improves. Efficacy of preservation fluids hence reduction of ischaemia injury may become enhanced by such additives as ion channel blockers, enzyme inhibitors, haeme oxygenase modulators, endothelin-l-inhibitors, quenchers of free radicals and anti-apoptotic agents. Many of these compounds, albeit of great theoretical interest, have not (yet?) made their way into clinical practice. This contribution is a survey of some promising agents, concentration and physicochemical interactions of which are analysed in some detail.
Keywords Acetylcysteine/pharmacologyAnimalsApoptosis/drug effectsCalcium Channel Blockers/pharmacologyFluorocarbons/pharmacologyHeme Oxygenase (Decyclizing)/physiologyHeme Oxygenase-1HumansHydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacologyMembrane ProteinsOrgan PreservationOrgan Preservation Solutions/pharmacologyTemperatureTrimetazidine/pharmacology
PMID: 12180834
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NYDEGGER, U E et al. New concepts in organ preservation. In: Transplant Immunology, 2002, vol. 9, n° 2-4, p. 215-25.

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Deposited on : 2014-09-24

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