UNIGE document Scientific Article
previous document  unige:38568  next document
add to browser collection
Title

Abnormal junctions and permeability of myelin in PMP22-deficient nerves

Authors
Guo, Jiasong
Wang, Leiming
Zhang, Yang
Wu, Jiawen
Arpag, Sezgi
Hu, Bo
Tian, Xinxia
show hidden authors show all authors [1 - 11]
Published in Annals of Neurology. 2014, vol. 75, no. 2, p. 255-65
Abstract The peripheral myelin protein-22 (PMP22) gene is associated with the most common types of inherited neuropathies, including hereditary neuropathy with liability to pressure palsies (HNPP) caused by PMP22 deficiency. However, the function of PMP22 has yet to be defined. Our previous study has shown that PMP22 deficiency causes an impaired propagation of nerve action potentials in the absence of demyelination. In the present study, we tested an alternative mechanism relating to myelin permeability.
Keywords Action Potentials/drug effects/geneticsAge FactorsAnimalsArthrogryposis/genetics/metabolismAxons/drug effects/metabolism/pathologyDisease Models, AnimalGene Expression Regulation/geneticsHEK293 CellsHereditary Sensory and Motor Neuropathy/genetics/metabolismHumansJunctional Adhesion Molecules/metabolismMiceMice, TransgenicMutation/geneticsMyelin Proteins/deficiencyMyelin Sheath/metabolismNeural Conduction/drug effects/geneticsPeripheral Nerves/metabolism/pathologyPotassium/pharmacologyTight Junction Proteins/metabolismTight Junctions/genetics/metabolism/pathology
Identifiers
PMID: 24339129
Full text
Article (Published version) (953 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Molécules d'adhésion et processus de migration cellulaire (167)
Citation
(ISO format)
GUO, Jiasong et al. Abnormal junctions and permeability of myelin in PMP22-deficient nerves. In: Annals of Neurology, 2014, vol. 75, n° 2, p. 255-65. https://archive-ouverte.unige.ch/unige:38568

138 hits

3 downloads

Update

Deposited on : 2014-07-09

Export document
Format :
Citation style :