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Tight junction dynamics: the role of junctional adhesion molecules (JAMs)

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Published in Cell and Tissue Research. 2014, vol. 355, no. 3, p. 701-15
Abstract Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the tight junction of polarized cells and on the cell surface of leukocytes. The last 20 years of research in this field has shown that several members of the family play an important role in the regulation of cell polarity, endothelium permeability and leukocytes migration. They mediate these pleiotropic functions through a multitude of homophilic and heterophilic interactions with intrafamily and extrafamily partners. In this article, we review the current status of the JAM family and highlight their functional role in tight junction dynamics and leukocyte transmigration.
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PMID: 24595739
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Article (Published version) (3.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Molécules d'adhésion et processus de migration cellulaire (167)
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GARRIDO-URBANI, Sarah, BRADFIELD, Paul, IMHOF, Beat. Tight junction dynamics: the role of junctional adhesion molecules (JAMs). In: Cell and Tissue Research, 2014, vol. 355, n° 3, p. 701-15. https://archive-ouverte.unige.ch/unige:38564

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Deposited on : 2014-07-08

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