Scientific article

Tight junction dynamics: the role of junctional adhesion molecules (JAMs)

Published inCell and tissue research, vol. 355, no. 3, p. 701-715
Publication date2014

Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the tight junction of polarized cells and on the cell surface of leukocytes. The last 20 years of research in this field has shown that several members of the family play an important role in the regulation of cell polarity, endothelium permeability and leukocytes migration. They mediate these pleiotropic functions through a multitude of homophilic and heterophilic interactions with intrafamily and extrafamily partners. In this article, we review the current status of the JAM family and highlight their functional role in tight junction dynamics and leukocyte transmigration.

Citation (ISO format)
GARRIDO-URBANI, Sarah, BRADFIELD, Paul, IMHOF, Beat. Tight junction dynamics: the role of junctional adhesion molecules (JAMs). In: Cell and tissue research, 2014, vol. 355, n° 3, p. 701–715. doi: 10.1007/s00441-014-1820-1
Main files (1)
Article (Published version)
ISSN of the journal0302-766X

Technical informations

Creation07/03/2014 12:27:00 PM
First validation07/03/2014 12:27:00 PM
Update time03/14/2023 9:26:07 PM
Status update03/14/2023 9:26:07 PM
Last indexation01/16/2024 11:17:57 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack