UNIGE document Scientific Article - Review
previous document  unige:38563  next document
add to browser collection

ERO, NADPH oxydases et vascularisation des tumeurs

Published in Medecine Sciences. 2014, vol. 30, no. 4, p. 415-21
Abstract Oxidative stress is the result of an imbalance between the production of reactive oxygen species (ROS) and antioxidant mechanisms. It is characterized by damage of all cellular components, DNA, proteins, lipids. ROS are nevertheless important for the physiology of an organism, as they are involved in the innate immune defense and several intracellular signaling pathways. They play an important role in tumorigenesis by promoting tumor vasculature, which is essential to their growth and metastatic processes. There are many sources of ROS in the cells, but the NOX enzymes (NADPH oxidase-dependent) are now recognized to have a major role in the oxidative stress process. Indeed, they are present in many tissues where their only function is to produce ROS. This article discusses the NOX in endothelial cells and their role in the tumor angiogenesis.
PMID: 24801037
Full text
Article (Published version) (2.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Molécules d'adhésion et processus de migration cellulaire (167)
(ISO format)
GARRIDO-URBANI, Sarah, JAQUET, Vincent, IMHOF, Beat. ERO, NADPH oxydases et vascularisation des tumeurs. In: Médecine/Sciences, 2014, vol. 30, n° 4, p. 415-21. doi: 10.1051/medsci/20143004016 https://archive-ouverte.unige.ch/unige:38563

445 hits

0 download


Deposited on : 2014-07-08

Export document
Format :
Citation style :