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Scientific article
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English

Long-term follow-up of the imatinib GRAAPH-2003 study in newly diagnosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL study

Published inBiology of blood and marrow transplantation, vol. 19, no. 1, p. 150-155
Publication date2013
Abstract

We report here the results of the GRAAPH-2003 trial with long-term follow-up in 45 patients with de novo Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Imatinib-based strategy improved the 4-year overall survival (OS) up to 52% versus 20% in the pre-imatinib LALA-94 trial (P = .0001). Despite the selection in patients who actually underwent transplantation, these results suggest that allogeneic or autologous stem cell transplants (SCTs) still have a place in overcoming the poor prognosis of Ph+ ALL in the era of imatinib therapy. OS was 50% after allogeneic SCT (24 patients), 33% in patients without a transplantation (9 patients), and 80% after autologous SCT (10 patients without allogeneic donor or >55 years, including 7 patients in complete molecular response).

Keywords
  • Adolescent
  • Adult
  • Age Factors
  • Antineoplastic Agents/administration & dosage/adverse effects
  • Benzamides/administration & dosage/adverse effects
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Middle Aged
  • Philadelphia Chromosome
  • Piperazines/administration & dosage/adverse effects
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality/therapy
  • Pyrimidines/administration & dosage/adverse effects
  • Survival Rate
  • Time Factors
  • Transplantation, Autologous
  • Transplantation, Homologous
  • Unrelated Donors
Citation (ISO format)
TANGUY-SCHMIDT, Aline et al. Long-term follow-up of the imatinib GRAAPH-2003 study in newly diagnosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL study. In: Biology of blood and marrow transplantation, 2013, vol. 19, n° 1, p. 150–155. doi: 10.1016/j.bbmt.2012.08.021
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Article (Published version)
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ISSN of the journal1083-8791
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