UNIGE document Scientific Article
previous document  unige:37154  next document
add to browser collection
Title

Long-term follow-up of the imatinib GRAAPH-2003 study in newly diagnosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL study

Authors
Tanguy-Schmidt, Aline
Rousselot, Philippe
Cayuela, Jean-Michel
Hayette, Sandrine
Vekemans, Marie-Christiane
Escoffre, Martine
Huguet, Françoise
show hidden authors show all authors [1 - 15]
Published in Biology of Blood and Marrow Transplantation. 2013, vol. 19, no. 1, p. 150-5
Abstract We report here the results of the GRAAPH-2003 trial with long-term follow-up in 45 patients with de novo Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Imatinib-based strategy improved the 4-year overall survival (OS) up to 52% versus 20% in the pre-imatinib LALA-94 trial (P = .0001). Despite the selection in patients who actually underwent transplantation, these results suggest that allogeneic or autologous stem cell transplants (SCTs) still have a place in overcoming the poor prognosis of Ph+ ALL in the era of imatinib therapy. OS was 50% after allogeneic SCT (24 patients), 33% in patients without a transplantation (9 patients), and 80% after autologous SCT (10 patients without allogeneic donor or >55 years, including 7 patients in complete molecular response).
Keywords AdolescentAdultAge FactorsAntineoplastic Agents/administration & dosage/adverse effectsBenzamides/administration & dosage/adverse effectsDisease-Free SurvivalFemaleFollow-Up StudiesHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedPhiladelphia ChromosomePiperazines/administration & dosage/adverse effectsPrecursor Cell Lymphoblastic Leukemia-Lymphoma/mortality/therapyPyrimidines/administration & dosage/adverse effectsSurvival RateTime FactorsTransplantation, AutologousTransplantation, HomologousUnrelated Donors
Identifiers
PMID: 22960387
Full text
Article (Published version) (605 Kb) - public document Free access
Structures
Citation
(ISO format)
TANGUY-SCHMIDT, Aline et al. Long-term follow-up of the imatinib GRAAPH-2003 study in newly diagnosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL study. In: Biology of Blood and Marrow Transplantation, 2013, vol. 19, n° 1, p. 150-5. https://archive-ouverte.unige.ch/unige:37154

315 hits

191 downloads

Update

Deposited on : 2014-06-04

Export document
Format :
Citation style :