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Scientific article
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English

The impact of T-cell depletion techniques on the outcome after haploidentical hematopoietic SCT

Contributors

Marek, A; Stern, M; Chalandon, Yves; Ansari Djaberi, Marc Georges; Ozsahin, Ayse Hulya; Güngör, T; Gerber, B; Kühne, T; Passweg, J R; Gratwohl, A; Tichelli, A; Seger, R; Schanz, U; Halter, J; Stussi, G

Published in

Bone marrow transplantation, vol. 49, no. 1, p. 55-61

Publication date

2014

Abstract

Several T-cell depletion (TCD) techniques are used for haploidentical hematopoietic SCT (HSCT), but direct comparisons are rare. We therefore studied the effect of in vitro TCD with graft engineering (CD34 selection or CD3/CD19 depletion, 74%) or in vivo TCD using alemtuzumab (26%) on outcome, immune reconstitution and infections after haploidentical HSCT. We performed a retrospective multicenter analysis of 72 haploidentical HSCT in Switzerland. Sixty-seven patients (93%) had neutrophil engraftment. The 1-year OS, TRM and relapse incidence were 48 (36-60)%, 20 (11-33)% and 42 (31-57)%, respectively, without differences among the TCD groups. In vivo TCD caused more profound lymphocyte suppression early after HSCT, whereas immune recovery beyond the second month was comparable between the two groups. Despite anti-infective prophylaxis, most patients experienced post-transplant infectious complications (94%). Patients with in vivo TCD had a higher incidence of CMV reactivations (54% vs 28%, P=0.015), but this did not result in a higher TRM. In conclusion, TCD by graft engineering or alemtuzumab are equally effective for haploidentical HSCT.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MAREK, A et al. The impact of T-cell depletion techniques on the outcome after haploidentical hematopoietic SCT. In: Bone marrow transplantation, 2014, vol. 49, n° 1, p. 55–61. doi: 10.1038/bmt.2013.132

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Article (Published version)

Identifiers

Journal ISSN

0268-3369
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489downloads

Technical informations

Creation

31/05/2014 17:56:00

First validation

31/05/2014 17:56:00

Update

13/10/2025 22:43:34

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14/03/2023 21:17:32

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