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Title

High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study

Authors
Terwijn, Monique
van Putten, Wim L J
Kelder, Angèle
van der Velden, Vincent H J
Brooimans, Rik A
Pabst, Thomas
Maertens, Johan
Boeckx, Nancy
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Published in Journal of Clinical Oncology. 2013, vol. 31, no. 31, p. 3889-97
Abstract Half the patients with acute myeloid leukemia (AML) who achieve complete remission (CR), ultimately relapse. Residual treatment-surviving leukemia is considered responsible for the outgrowth of AML. In many retrospective studies, detection of minimal residual disease (MRD) has been shown to enable identification of these poor-outcome patients by showing its independent prognostic impact. Most studies focus on molecular markers or analyze data in retrospect. This study establishes the value of immunophenotypically assessed MRD in the context of a multicenter clinical trial in adult AML with sample collection and analysis performed in a few specialized centers.
Keywords AdolescentAdultConsolidation Chemotherapy/methodsFemaleFlow Cytometry/methodsGranulocyte Colony-Stimulating Factor/administration & dosageHumansInduction Chemotherapy/methodsLeukemia, Myeloid, Acute/diagnosis/drug therapyMaleMiddle AgedNeoplasm Recurrence, Local/diagnosisNeoplasm, Residual/diagnosisPrognosisProportional Hazards ModelsRemission InductionYoung Adult
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PMID: 24062400
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TERWIJN, Monique et al. High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study. In: Journal of Clinical Oncology, 2013, vol. 31, n° 31, p. 3889-97. https://archive-ouverte.unige.ch/unige:37145

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Deposited on : 2014-06-04

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