UNIGE document Scientific Article
previous document  unige:35499  next document
add to browser collection
Title

Comparison of the glomerular filtration rate in children by the new revised Schwartz formula and a new generalized formula

Authors
Gao, Anja
Cachat, Francois
Faouzi, Mohamed
Bardy, Daniel
Mosig, Dolores
Meyrat, Blaise-Julien
Chehade, Hassib
Published in Kidney International. 2013, vol. 83, no. 3, p. 524-30
Abstract The most widely used formula for estimating glomerular filtration rate (eGFR) in children is the Schwartz formula. It was revised in 2009 using iohexol clearances with measured GFR (mGFR) ranging between 15 and 75 ml/min × 1.73 m(2). Here we assessed the accuracy of the Schwartz formula using the inulin clearance (iGFR) method to evaluate its accuracy for children with less renal impairment comparing 551 iGFRs of 392 children with their Schwartz eGFRs. Serum creatinine was measured using the compensated Jaffe method. In order to find the best relationship between iGFR and eGFR, a linear quadratic regression model was fitted and a more accurate formula was derived. This quadratic formula was: 0.68 × (Height (cm)/serum creatinine (mg/dl))-0.0008 × (height (cm)/serum creatinine (mg/dl))(2)+0.48 × age (years)-(21.53 in males or 25.68 in females). This formula was validated using a split-half cross-validation technique and also externally validated with a new cohort of 127 children. Results show that the Schwartz formula is accurate until a height (Ht)/serum creatinine value of 251, corresponding to an iGFR of 103 ml/min × 1.73 m(2), but significantly unreliable for higher values. For an accuracy of 20 percent, the quadratic formula was significantly better than the Schwartz formula for all patients and for patients with a Ht/serum creatinine of 251 or greater. Thus, the new quadratic formula could replace the revised Schwartz formula, which is accurate for children with moderate renal failure but not for those with less renal impairment or hyperfiltration.
Keywords AdolescentChildChild, PreschoolCreatinine/bloodCystatin C/bloodFemaleGlomerular Filtration RateHumansMaleMathematics
Identifiers
PMID: 23254901
Full text
Article (Published version) (631 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
Citation
(ISO format)
GAO, Anja et al. Comparison of the glomerular filtration rate in children by the new revised Schwartz formula and a new generalized formula. In: Kidney International, 2013, vol. 83, n° 3, p. 524-30. https://archive-ouverte.unige.ch/unige:35499

204 hits

0 download

Update

Deposited on : 2014-04-08

Export document
Format :
Citation style :