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Nonautonomous movement of chromosomes in mitosis

Vladimirou, Elina
Mchedlishvili, Nunu
Armond, Jonathan W
Samora, Catarina P
McAinsh, Andrew D
Published in Developmental Cell. 2013, vol. 27, no. 1, p. 60-71
Abstract Kinetochores are the central force-generating machines that move chromosomes during cell division. It is generally assumed that kinetochores move in an autonomous manner. However, we reveal here that movements of neighboring sister-kinetochore pairs in metaphase are correlated in a distance-dependent manner. This correlation increases in the absence of kinetochore oscillations or stable end-on attachments. This suggests that periodic movements of bioriented chromosomes limit the correlated motion of nonsisters. Computer simulations show that these correlated movements can occur when elastic crosslinks are placed between the K-fibers of oscillating kinetochores. Strikingly, inhibition of the microtubule crosslinking motor kinesin-5 Eg5 leads to an increase in nonsister correlation and impairs periodic oscillations. These phenotypes are partially rescued by codepletion of the kinesin-12 Kif15, demonstrating a function for kinesin-5 and kinesin-12 motors in driving chromosome movements, possibly as part of a crosslinking structure that correlates the movements of nonsister kinetochores.
PMID: 24135231
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Research group Groupe Meraldi Patrick (physiologie cellulaire et métabolisme) (922)
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VLADIMIROU, Elina et al. Nonautonomous movement of chromosomes in mitosis. In: Developmental Cell, 2013, vol. 27, n° 1, p. 60-71. https://archive-ouverte.unige.ch/unige:33721

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Deposited on : 2014-01-27

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