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Scientific article
English

Highly Modular C1-Symmetric Chiral (P,N) Ligands with a Stereolabile P Center: Experimental and Theoretical Studies

Published inChemistry, vol. 20, no. 3, p. 745-751
Publication date2014
Abstract

An improved synthesis of a novel class of bidentate (P,N) ligands is presented, the structures of which are characterized by three distinct elements of chirality. The stereoselective installation of the elements of central chirality (at the benzylic carbon and the phosphorus atom) depends on the size of the phosphorus substituent. Thermal inversion of the phosphorus center has been studied experimentally and further correlated by DFT calculations. The potential of these ligands and the role of the phosphorus atom in the asymmetric α-arylation of aldehydes (Pd) and hydrogenation of allylic alcohols (Ir) have also been investigated.

Keywords
  • Arylation
  • Asymmetric catalysis
  • Chirality
  • N,P ligands
  • Stereoinversion
Citation (ISO format)
HUMBERT, Nicolas et al. Highly Modular C<sub>1</sub>-Symmetric Chiral (P,N) Ligands with a Stereolabile P Center: Experimental and Theoretical Studies. In: Chemistry, 2014, vol. 20, n° 3, p. 745–751. doi: 10.1002/chem.201303146
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Identifiers
ISSN of the journal0947-6539
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