UNIGE document Scientific Article
previous document  unige:32971  next document
add to browser collection
Title

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field

Authors
Marques, José P
Kober, Tobias
Krueger, Gunnar
van der Zwaag, Wietske
Van de Moortele, Pierre-François
Published in NeuroImage. 2010, vol. 49, no. 2, p. 1271-81
Abstract The large spatial inhomogeneity in transmit B(1) field (B(1)(+)) observable in human MR images at high static magnetic fields (B(0)) severely impairs image quality. To overcome this effect in brain T(1)-weighted images, the MPRAGE sequence was modified to generate two different images at different inversion times, MP2RAGE. By combining the two images in a novel fashion, it was possible to create T(1)-weighted images where the result image was free of proton density contrast, T(2) contrast, reception bias field, and, to first order, transmit field inhomogeneity. MP2RAGE sequence parameters were optimized using Bloch equations to maximize contrast-to-noise ratio per unit of time between brain tissues and minimize the effect of B(1)(+) variations through space. Images of high anatomical quality and excellent brain tissue differentiation suitable for applications such as segmentation and voxel-based morphometry were obtained at 3 and 7 T. From such T(1)-weighted images, acquired within 12 min, high-resolution 3D T(1) maps were routinely calculated at 7 T with sub-millimeter voxel resolution (0.65-0.85 mm isotropic). T(1) maps were validated in phantom experiments. In humans, the T(1) values obtained at 7 T were 1.15+/-0.06 s for white matter (WM) and 1.92+/-0.16 s for grey matter (GM), in good agreement with literature values obtained at lower spatial resolution. At 3 T, where whole-brain acquisitions with 1 mm isotropic voxels were acquired in 8 min, the T(1) values obtained (0.81+/-0.03 s for WM and 1.35+/-0.05 for GM) were once again found to be in very good agreement with values in the literature.
Keywords AdultBrain/physiologyFemaleHumansMagnetic Resonance Imaging/methodsMalePhantoms, Imaging
Identifiers
PMID: 19819338
Full text
Article (Published version) (942 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group CIBM (863)
Citation
(ISO format)
MARQUES, José P et al. MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. In: NeuroImage, 2010, vol. 49, n° 2, p. 1271-81. https://archive-ouverte.unige.ch/unige:32971

251 hits

1 download

Update

Deposited on : 2014-01-08

Export document
Format :
Citation style :