MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field

Marques, José P; Kober, Tobias; Krueger, Gunnar; van der Zwaag, Wietske; Van de Moortele, Pierre-François; Gruetter, Rolf

doi:10.1016/j.neuroimage.2009.10.002

Scientific article

English

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field

Contributors

Marques, José P; Kober, Tobias; Krueger, Gunnar; van der Zwaag, Wietske; Van de Moortele, Pierre-François; Gruetter, Rolf

Published in

NeuroImage, vol. 49, no. 2, p. 1271-1281

Publication date

2010

Abstract

The large spatial inhomogeneity in transmit B(1) field (B(1)(+)) observable in human MR images at high static magnetic fields (B(0)) severely impairs image quality. To overcome this effect in brain T(1)-weighted images, the MPRAGE sequence was modified to generate two different images at different inversion times, MP2RAGE. By combining the two images in a novel fashion, it was possible to create T(1)-weighted images where the result image was free of proton density contrast, T(2) contrast, reception bias field, and, to first order, transmit field inhomogeneity. MP2RAGE sequence parameters were optimized using Bloch equations to maximize contrast-to-noise ratio per unit of time between brain tissues and minimize the effect of B(1)(+) variations through space. Images of high anatomical quality and excellent brain tissue differentiation suitable for applications such as segmentation and voxel-based morphometry were obtained at 3 and 7 T. From such T(1)-weighted images, acquired within 12 min, high-resolution 3D T(1) maps were routinely calculated at 7 T with sub-millimeter voxel resolution (0.65-0.85 mm isotropic). T(1) maps were validated in phantom experiments. In humans, the T(1) values obtained at 7 T were 1.15+/-0.06 s for white matter (WM) and 1.92+/-0.16 s for grey matter (GM), in good agreement with literature values obtained at lower spatial resolution. At 3 T, where whole-brain acquisitions with 1 mm isotropic voxels were acquired in 8 min, the T(1) values obtained (0.81+/-0.03 s for WM and 1.35+/-0.05 for GM) were once again found to be in very good agreement with values in the literature.

Keywords

Adult
Brain/physiology
Female
Humans
Magnetic Resonance Imaging/methods
Male
Phantoms, Imaging

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

UNIGE research groups

CIBM (863)

Citation (ISO format)

MARQUES, José P et al. MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. In: NeuroImage, 2010, vol. 49, n° 2, p. 1271–1281. doi: 10.1016/j.neuroimage.2009.10.002

Article (Published version)

Identifiers

PID : unige:32971
DOI : 10.1016/j.neuroimage.2009.10.002
PMID : 19819338

Journal ISSN

1053-8119

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Creation

12/12/2013 20:36:00

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12/12/2013 20:36:00

Update

14/03/2023 20:49:12

Status update

14/03/2023 20:49:12

Last indexation

30/10/2024 15:43:59

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation