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Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27

Published inSeminars in immunology, vol. 23, no. 6, p. 438-445
Publication date2011
Abstract

Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T(H)17 responses.

Keywords
  • Animals
  • Autoimmune Diseases/immunology
  • Humans
  • Interleukin-10/biosynthesis/immunology
  • Interleukins/immunology
  • T-Lymphocytes, Regulatory/immunology
  • Th17 Cells/immunology
Citation (ISO format)
POT, Caroline et al. Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. In: Seminars in immunology, 2011, vol. 23, n° 6, p. 438–445. doi: 10.1016/j.smim.2011.08.003
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ISSN of the journal1044-5323
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