UNIGE document Scientific Article - Review
previous document  unige:32745  next document
add to browser collection

Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27

Apetoh, Lionel
Awasthi, Amit
Kuchroo, Vijay K
Published in Seminars in immunology. 2011, vol. 23, no. 6, p. 438-45
Abstract Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T(H)17 responses.
Keywords AnimalsAutoimmune Diseases/immunologyHumansInterleukin-10/biosynthesis/immunologyInterleukins/immunologyT-Lymphocytes, Regulatory/immunologyTh17 Cells/immunology
PMID: 21893418
Full text
Article (Published version) (621 Kb) - public document Free access
Research group Groupe Pot-Kreis Caroline (931)
(ISO format)
POT, Caroline et al. Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. In: Seminars in immunology, 2011, vol. 23, n° 6, p. 438-45. doi: 10.1016/j.smim.2011.08.003 https://archive-ouverte.unige.ch/unige:32745

538 hits



Deposited on : 2014-01-02

Export document
Format :
Citation style :