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Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide |
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Published in | Critical care. 2011, vol. 15, no. 4, R181 | |
Abstract | Mechanical ventilation (MV) could prime the lung toward an inflammatory response if exposed to another insult such as bacterial invasion. The underlying mechanisms are not so far clear. Toll-like receptors (TLRs) allow the host to recognize selectively bacterial pathogens and in turn to trigger an immune response. We therefore hypothesized that MV modulates TLR2 expression and in turn modifies responsiveness to agonists such as bacterial lipopeptide (BLP). | |
Keywords | Animals — Bacteria/metabolism — Cell Culture Techniques — Epithelial Cells/metabolism/microbiology — Flow Cytometry — Interleukin-6/metabolism — Interleukin-8/metabolism — Lipopeptides/metabolism — Lung/immunology/metabolism — Male — Rabbits — Real-Time Polymerase Chain Reaction — Respiration, Artificial/methods — Sequence Analysis, DNA — Toll-Like Receptor 2/analysis/genetics/metabolism — Up-Regulation | |
Identifiers | DOI: 10.1186/cc10330 PMID: 21794115 | |
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Research group | Groupe Pugin Jérôme (Soins intensifs) (587) | |
Citation (ISO format) | CHARLES, Pierre-Emmanuel et al. Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide. In: Critical care, 2011, vol. 15, n° 4, p. R181. doi: 10.1186/cc10330 https://archive-ouverte.unige.ch/unige:32315 |