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Title

Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide

Authors
Barbar, Saber Davide
Croisier, Delphine
Chavanet, Pascal
Published in Critical Care. 2011, vol. 15, no. 4, p. R181
Abstract Mechanical ventilation (MV) could prime the lung toward an inflammatory response if exposed to another insult such as bacterial invasion. The underlying mechanisms are not so far clear. Toll-like receptors (TLRs) allow the host to recognize selectively bacterial pathogens and in turn to trigger an immune response. We therefore hypothesized that MV modulates TLR2 expression and in turn modifies responsiveness to agonists such as bacterial lipopeptide (BLP).
Keywords AnimalsBacteria/metabolismCell Culture TechniquesEpithelial Cells/metabolism/microbiologyFlow CytometryInterleukin-6/metabolismInterleukin-8/metabolismLipopeptides/metabolismLung/immunology/metabolismMaleRabbitsReal-Time Polymerase Chain ReactionRespiration, Artificial/methodsSequence Analysis, DNAToll-Like Receptor 2/analysis/genetics/metabolismUp-Regulation
Identifiers
PMID: 21794115
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Article (Published version) (5.9 MB) - public document Free access
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Research group Groupe Pugin Jérôme (Soins intensifs) (587)
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CHARLES, Pierre-Emmanuel et al. Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide. In: Critical Care, 2011, vol. 15, n° 4, p. R181. https://archive-ouverte.unige.ch/unige:32315

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Deposited on : 2013-12-17

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