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Title

Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide
Authors
Charles, Pierre-Emmanuel
Tissières, Pierre
Barbar, Saber Davide
Croisier, Delphine
Dufour, Julien
Dunn-Siegrist, Irène
Chavanet, Pascal
Pugin, Jérôme
Published in Critical Care. 2011, vol. 15, no. 4, p. R181
Abstract Mechanical ventilation (MV) could prime the lung toward an inflammatory response if exposed to another insult such as bacterial invasion. The underlying mechanisms are not so far clear. Toll-like receptors (TLRs) allow the host to recognize selectively bacterial pathogens and in turn to trigger an immune response. We therefore hypothesized that MV modulates TLR2 expression and in turn modifies responsiveness to agonists such as bacterial lipopeptide (BLP).
Keywords Animals — Bacteria/metabolism — Cell Culture Techniques — Epithelial Cells/metabolism/microbiology — Flow Cytometry — Interleukin-6/metabolism — Interleukin-8/metabolism — Lipopeptides/metabolism — Lung/immunology/metabolism — Male — Rabbits — Real-Time Polymerase Chain Reaction — Respiration, Artificial/methods — Sequence Analysis, DNA — Toll-Like Receptor 2/analysis/genetics/metabolism — Up-Regulation
Identifiers
PMID: 21794115
Full text
Article (Published version) (5.9 MB) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie et soins intensifs
Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group Groupe Pugin Jérôme (Soins intensifs) (587)
Citation
(ISO format) 		CHARLES, Pierre-Emmanuel et al. Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide. In: Critical Care, 2011, vol. 15, n° 4, p. R181. https://archive-ouverte.unige.ch/unige:32315

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Deposited on : 2013-12-17

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