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Scientific article
Open access
English

Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide

Published inCritical care, vol. 15, no. 4, R181
Publication date2011
Abstract

Mechanical ventilation (MV) could prime the lung toward an inflammatory response if exposed to another insult such as bacterial invasion. The underlying mechanisms are not so far clear. Toll-like receptors (TLRs) allow the host to recognize selectively bacterial pathogens and in turn to trigger an immune response. We therefore hypothesized that MV modulates TLR2 expression and in turn modifies responsiveness to agonists such as bacterial lipopeptide (BLP).

Keywords
  • Animals
  • Bacteria/metabolism
  • Cell Culture Techniques
  • Epithelial Cells/metabolism/microbiology
  • Flow Cytometry
  • Interleukin-6/metabolism
  • Interleukin-8/metabolism
  • Lipopeptides/metabolism
  • Lung/immunology/metabolism
  • Male
  • Rabbits
  • Real-Time Polymerase Chain Reaction
  • Respiration, Artificial/methods
  • Sequence Analysis, DNA
  • Toll-Like Receptor 2/analysis/genetics/metabolism
  • Up-Regulation
Citation (ISO format)
CHARLES, Pierre-Emmanuel et al. Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide. In: Critical care, 2011, vol. 15, n° 4, p. R181. doi: 10.1186/cc10330
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1364-8535
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237downloads

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