UNIGE document Scientific Article
previous document  unige:31988  next document
add to browser collection
Title

Volumetric and topographic differences in hippocampal subdivisions in borderline personality and bipolar disorders

Authors
Rossi, Roberta
Lanfredi, Mariangela
Pievani, Michela
Beneduce, Rossella
Rillosi, Luciana
Thompson, Paul M
show hidden authors show all authors [1 - 10]
Published in Psychiatry Research: Neuroimaging. 2012, vol. 203, no. 2-3, p. 132-8
Abstract Hippocampal abnormalities may be implicated in the pathophysiology of mental disorders with affective symptoms such as borderline personality disorder (BPD) and bipolar disorder (BD). We aimed to investigate hippocampal morphology in BPD and BD patients, compared to 1:1 age- and sex-matched healthy controls (HC) using a three-dimensional mapping method. Manual tracing of the hippocampi on magnetic resonance imaging (MRI) images was performed on 26 patients with BPD (age: 38±11; sex (f): 16 (61%)) and 15 with BD (age: 44±9; sex (f): 5 (33%)) and their age- and sex-matched HC (for BPD: n=26; age: 38±11; sex (f): 16 (61%); for BD: n=15; age: 44±9; sex (f): 5 (33%)). Compared to their reference groups, BPD patients showed smaller hippocampal volume bilaterally. The BD group showed significantly smaller right hippocampal volumes. In the surface maps, alterations were localized to different hippocampal sectors for the two groups: the CA1 regions and subiculum, bilaterally, in BPD, and the right dentate gyrus in the BD group. These differences persisted after controlling for alcohol and substance abuse. BPD and BD groups may exhibit distinct patterns of volumetric MRI changes in hippocampal subdivisions that might be related to the clinical phenomenology of each disorder.
Keywords AdultBorderline Personality Disorder/diagnosis/pathologyBrain MappingDominance, Cerebral/physiologyFemaleHippocampus/pathologyHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedOrgan Size/physiologyReference Values
Identifiers
PMID: 22944368
Full text
Article (Published version) (540 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
Citation
(ISO format)
ROSSI, Roberta et al. Volumetric and topographic differences in hippocampal subdivisions in borderline personality and bipolar disorders. In: Psychiatry Research: Neuroimaging, 2012, vol. 203, n° 2-3, p. 132-8. https://archive-ouverte.unige.ch/unige:31988

183 hits

0 download

Update

Deposited on : 2013-12-10

Export document
Format :
Citation style :