Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials

Blaudszun, Grégoire; Lysakowski, Christopher; Elia, Nadia; Tramer, Martin

doi:10.1097/ALN.0b013e31825681cb

Scientific article

Meta-analysis

English

Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials

ContributorsBlaudszun, Grégoire; Lysakowski, Christopher; Elia, Nadia; Tramer, Martin

Published inAnesthesiology, vol. 116, no. 6, p. 1312-1322

Publication date2012

Abstract

Systemic α2 agonists are believed to reduce pain and opioid requirements after surgery, thus decreasing the incidence of opioid-related adverse effects, including hyperalgesia.

Keywords

Adrenergic alpha-2 Receptor Agonists/therapeutic use
Analgesics, Opioid/administration & dosage/adverse effects/therapeutic use
Anesthesia Recovery Period
Clonidine/therapeutic use
Dexmedetomidine/pharmacology
Hemodynamics/drug effects
Humans
Hyperalgesia/chemically induced/prevention & control
Hypotension/chemically induced/epidemiology
Morphine/administration & dosage/adverse effects/therapeutic use
Pain Measurement/drug effects
Pain, Postoperative/drug therapy/psychology
Postoperative Nausea and Vomiting/drug therapy/epidemiology
Randomized Controlled Trials as Topic

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research groups

La Médecine Périopératoire et l'anesthésie (70)

Citation (ISO format)

BLAUDSZUN, Grégoire et al. Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. In: Anesthesiology, 2012, vol. 116, n° 6, p. 1312–1322. doi: 10.1097/ALN.0b013e31825681cb

Article (Published version)

Identifiers

PID : unige:31966
DOI : 10.1097/ALN.0b013e31825681cb
PMID : 22546966

Journal ISSN0003-3022

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First validation28/10/2013 16:17:00

Update time14/03/2023 20:42:06

Status update14/03/2023 20:42:06

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Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials

Systemic α2 agonists are believed to reduce pain and opioid requirements after surgery, thus decreasing the incidence of opioid-related adverse effects, including hyperalgesia.

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