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Scientific article
English

Cell polarity and asymmetric cell division: the C. elegans early embryo

Published inEssays in biochemistry, vol. 53, p. 1-14
Publication date2012
Abstract

Cell polarity is crucial for many functions including cell migration, tissue organization and asymmetric cell division. In animal cells, cell polarity is controlled by the highly conserved PAR (PARtitioning defective) proteins. par genes have been identified in Caenorhabditis elegans in screens for maternal lethal mutations that disrupt cytoplasmic partitioning and asymmetric division. Although PAR proteins were identified more than 20 years ago, our understanding on how they regulate polarity and how they are regulated is still incomplete. In this chapter we review our knowledge of the processes of cell polarity establishment and maintenance, and asymmetric cell division in the early C. elegans embryo. We discuss recent findings that highlight new players in cell polarity and/or reveal the molecular details on how PAR proteins regulate polarity processes.

Keywords
  • Animals
  • Asymmetric Cell Division/genetics
  • Caenorhabditis elegans/embryology/genetics/physiology
  • Caenorhabditis elegans Proteins/genetics/metabolism
  • Cell Polarity/genetics
  • Embryo, Nonmammalian/physiology
  • Mitotic Spindle Apparatus/genetics/metabolism
  • Signal Transduction
Citation (ISO format)
NOATYNSKA, Anna, GOTTA, Monica. Cell polarity and asymmetric cell division: the C. elegans early embryo. In: Essays in biochemistry, 2012, vol. 53, p. 1–14. doi: 10.1042/bse0530001
Identifiers
ISSN of the journal0071-1365
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